omega-(4-iodophenyl)pentadecanoic acid (IPPA)

imaging agent; RN given refers to parent cpd without isomeric designation

Also Known As:

IPPA; 123I-pPPA; 15-(4-iodophenyl)pentadecanoic acid; 4-(iodophenyl)pentadecanoic acid; OIPPDA; iodo-para-phenyldecanoic acid; omega-(4-iodophenyl)pentadecanoic acid, 123I-labeled cpd; omega-(4-iodophenyl)pentadecanoic acid, 125I-labeled cpd; omega-(4-iodophenyl)pentadecanoic acid, 131I-labeled cpd; omega-(p-iodophenyl)pentadecanoic acid; p-IPPA; Benzenepentadecanoic acid, 4-(iodo-123I)-

Networked: 44 relevant articles (7 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Iodobenzenes
        omega-(4-iodophenyl)pentadecanoic acid: 44
  - Halogenated Hydrocarbons: 42
    - Iodinated Hydrocarbons
      - Iodobenzenes
        omega-(4-iodophenyl)pentadecanoic acid: 44

Experts

1.	Bryńska, Anita: 1 article (10/2021)
2.	Konowałek, Łukasz: 1 article (10/2021)
3.	Lenkiewicz, Kamila: 1 article (10/2021)
4.	Estévez, Ana: 1 article (06/2021)
5.	Jauregui, Paula: 1 article (06/2021)
6.	López-González, Hibai: 1 article (06/2021)
7.	Macía, Laura: 1 article (06/2021)
8.	Kaasbøll, Jannike: 1 article (01/2021)
9.	Lydersen, Stian: 1 article (01/2021)
10.	Skokauskas, Norbert: 1 article (01/2021)

Related Diseases

1.	Coronary Artery Disease (Coronary Atherosclerosis) 07/01/1988 - "The first hypothesis was that IPPA imaging with single photon emission computed tomography (SPECT) is useful in the identification of patients with coronary artery disease. " 06/01/1988 - "The double-nuclide method for IPPA-EF determination allows to eliminate the influence of flow in FFA imaging and enhances the potential of scintigraphy in the differential diagnosis of HHD versus coronary artery disease." 07/01/1988 - "Using the limits of normal as 2 SD from the normal mean values, 27 of the 33 patients with coronary artery disease demonstrated abnormalities in either the initial distribution or the clearance of IPPA, or both. " 04/01/1994 - "Initial research in dogs and later research in normal volunteers and patients with coronary artery disease indicated that 123I-iodophenylpentadecanoic acid (IPPA) can provide valuable diagnostic information. " 11/01/1988 - "In 15 normal subjects and 30 patients with coronary artery disease, 201Tl and 15-(p-123I-iodophenyl)-pentadecanoic acid (IPPA) were administered during exercise under fasting conditions and at rest. "
2.	Myocardial Ischemia (Ischemic Heart Diseases) 06/01/1990 - "The postexercise heterogeneity in IPPA uptake and delayed washout in segments with reduced initial uptake is consistent with exercise-induced myocardial ischemia in patients with LVH." 01/01/1990 - "We conclude that [123I]IPPA is a useful indicator of developing myocardial ischemia." 10/01/1989 - "Myocardial imaging with IPPA should be useful not only for myocardial metabolic diseases (cardiomyopathy etc.) but also for ischemic heart disease." 01/01/1990 - "Imaging 123I-labeled iodophenylpentadecanoic acid (IPPA) uptake and clearance from the myocardium following exercise has been advocated as a means of detecting myocardial ischemia because fatty acid deposition is enhanced and clearance prolonged in regions of low flow. " 11/01/1986 - "In this study, we tested the hypothesis that myocardial ischemia induced by exercise in patients is associated with diminished metabolism and/or delayed clearance of an intravenously injected fatty acid, iodine 123-labeled phenylpentadecanoic acid (IPPA). "
3.	Ischemia 03/01/2002 - "In a canine model of regional low-flow ischemia (n = 9), serial IPPA SPECT images (2 min per image) were acquired over 52--90 min. In a subset of dogs (n = 6), (18)F-FDG was injected after completing SPECT imaging and allowed to accumulate for 40 min before killing the animals. " 04/01/1989 - "These findings indicate reduced cardiac utilization and delayed oxidation of IPPA, associated with exercise-induced ischemia in CAD. " 01/01/1988 - "Efficacy of 15-(123I)-p-iodophenyl pentadecanoic acid (IPPA) in assessing myocardial metabolism in a model of reversible global ischemia." 03/01/2002 - "This study evaluated the potential of dynamic SPECT imaging of a FFA analog, p-(123)I-iodophenylpentadecanoic acid (IPPA), for detection of ischemia and compares retention of IPPA with (18)F-FDG accumulation. " 07/01/1988 - "The second hypothesis tested was that IPPA imaging is as or more sensitive and, therefore, complementary to thallium-201 imaging in the identification of exercise-induced ischemia in patients. "
4.	Infarction (Infarctions) 10/01/1999 - "In patients with improved regional wall motion, the MIBI scans and the IPPA scans showed (non-significant) decreases in defect size and increases in infarct and peri-infarct zone uptake after bypass surgery. " 10/01/1999 - "In nine patients with improved regional echocardiographic wall motion score after bypass surgery, the pre-operative uptake values of both MIBI and IPPA in the infarct and peri-infarct zones were on average slightly but not significantly higher than in 19 patients with no observed improvement in regional wall motion score. " 10/01/1999 - "The IPPA uptake increased in the infarct zones from 37%+/-11% to 44%+/-13% (P<0.001), and in the peri-infarct zones from 51%+/-11% to 57%+/-12% (P<0.05). " 03/01/1995 - "The volunteers were remarkable for homogeneous uptake and metabolism of IPPA; 13 of 14 infarct patients showed areas of decreased uptake > 2 SDs below the mean of the volunteers. " 06/07/1991 - "In 25 out of 31 patients (81%) with myocardial infarction, IPPA scintigraphy infarct localization agreed with the clinical findings. "
5.	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 11/01/1988 - "Patients with congestive cardiomyopathy demonstrated significantly greater heterogeneity of IPPA uptake than normal subjects (maximal percent variation of activity 27 +/- 11 vs 18 +/- 4, p less than 0.01). " 06/01/1988 - "In dilated cardiomyopathy (DCM) both IPPA-EF and 201Tl uptake showed distinct regional variations and a great interindividual variability with a mean IPPA-EF reduction of 12% (N = 9). " 11/01/1988 - "Nine normal volunteers and 19 patients with dilated cardiomyopathy of various etiologies underwent cardiac imaging with single-photon emission computed tomography (SPECT) after intravenous injection of IPPA. "

Related Drugs and Biologics

1.	Acids
2.	Fatty Acids (Saturated Fatty Acids)
3.	Iodine
4.	pentadecanoic acid
5.	Aligeron (AS 2)
6.	Iodine-123
7.	Thallium-201
8.	Isotopes
9.	Thallium
10.	Indicators and Reagents (Reagents)

Related Therapies and Procedures

1.	Gamma Cameras (Gamma Camera)
2.	Intravenous Injections
3.	Aftercare (After-Treatment)