7 alpha-hydroxysteroid dehydrogenase

Also Known As:

7 alpha-dehydroxylase; 7-alpha-hydroxysteroid dehydrogenase; 7alpha-hydroxycholesterol dehydrogenase; 7alpha-hydroxysteroid dehydrogenase; bile acid 7 alpha-dehydroxylase; bile acid 7-alpha-dehydroxylase; bile acid 7-dehydroxylase; cholic acid 7alpha-dehydroxylase

Networked: 6 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Alcohol Oxidoreductases: 56
      - Hydroxysteroid Dehydrogenases: 313
        7 alpha-hydroxysteroid dehydrogenase: 6

Experts

1.	Ganopolsky, Jorge G: 1 article (01/2014)
2.	Jones, Mitchell L: 1 article (01/2014)
3.	Labbé, Alain: 1 article (01/2014)
4.	Martoni, Christopher J: 1 article (01/2014)
5.	Prakash, Satya: 1 article (01/2014)
6.	Dowling, R H: 1 article (12/2001)
7.	French, G: 1 article (12/2001)
8.	Hylemon, P B: 1 article (12/2001)
9.	Murphy, G M: 1 article (12/2001)
10.	Thomas, L A: 1 article (12/2001)

Related Diseases

1.	Alcoholic Liver Cirrhosis (Alcoholic Cirrhosis) 08/01/1976 - "The marked decrease in 7 alpha-dehydroxylase activity of fecal bacteria of some patients with alcoholic cirrhosis results in impaired conversion of cholate to deoxycholate and explains the lack of biliary deoxycholate in these patients."
2.	Carcinogenesis 05/15/1996 - "In the present study, we investigated the effect of high-fat diets that are rich in omega-3 and omega-6 fatty acids on cecal bacterial 7 alpha-dehydroxylase and PI-PLC, fecal secondary bile acids, and colonic mucosal DAG kinase and PKC activities during different stages of colon carcinogenesis in male F344 rats. " 05/15/1996 - "The mechanisms by which the high fat content of the diet promotes colon carcinogenesis may include the production of secondary bile acids in the colon and the modulation of colonic luminal bacterial 7 alpha-dehydroxylase that is involved in generating secondary bile acids, phosphatidylinositol-specific phospholipase C (PI-PLC), and mucosal PI-PLC, as well as diacylglycerol (DAG) kinase and protein kinase C (PKC). "
3.	Colonic Neoplasms (Colon Cancer) 05/01/1992 - "Because of the potential significance of colonic bacteria and secondary bile acids in the pathogenesis of colon cancer, the present study investigated the effect of different types of dietary fiber on fecal bacterial enzymes, namely, beta-glucuronidase, 7 alpha-dehydroxylase, nitroreductase, and azoreductase, and on bile acids and neutral sterols in premenopausal women. "
4.	Neoplasms (Cancer) 10/01/1978 - "A plot of pH value versus NADP-dependent 7alpha-hydroxysteroid dehydrogenase tended to separate the cancer patients from the other groups. " 10/01/1978 - "A significant intergroup difference was observed in the amounts of NAD- and NADP-dependent 7alpha-hydroxysteroid dehydrogenase produced: bowel cancer patients exceeded controls, and controls exceeded Seventh-Day Adventists. " 05/15/1996 - "Effect of amount and types of dietary fat on intestinal bacterial 7 alpha-dehydroxylase and phosphatidylinositol-specific phospholipase C and colonic mucosal diacylglycerol kinase and PKC activities during stages of colon tumor promotion."
5.	Gallstones (Gallstone) 12/01/2001 - "Deoxycholic acid (DCA), implicated in the pathogenesis of gall stones and colorectal cancer, is mainly formed by bacterial deconjugation (cholylglycine hydrolase (CGH)) and 7 alpha-dehydroxylation (7 alpha-dehydroxylase (7 alpha-DH)) of conjugated cholic acid (CA) in the caecum/proximal colon. "

Related Drugs and Biologics

1.	Deoxycholic Acid (Sodium Deoxycholate)
2.	Cholates
3.	Bile Acids and Salts (Bile Acids)
4.	Omega-6 Fatty Acids (Omega 6 Fatty Acids)
5.	Diacylglycerol Kinase
6.	Sterols
7.	Nitroreductases
8.	Glucuronidase
9.	Enzymes
10.	Dietary Fiber