corticosterone methyl oxidase II

catalyzes the ultimate step on aldosterone biosynthesis: from 18-hydroxycorticosterone to aldosterone

Also Known As:

CMO II

Networked: 6 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxygenases: 333
      - Mixed Function Oxygenases: 2175
        Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 11: 13
        Cytochrome P-450 CYP11B2: 697
        corticosterone methyl oxidase II: 6
        Steroid Hydroxylases: 11
        Cytochrome P-450 CYP11B2: 697
        corticosterone methyl oxidase II: 6
- Cytochromes: 2196
  - Cytochrome P-450 Enzyme System: 5365
    - Cytochrome P450 Family 11: 13
      - Cytochrome P-450 CYP11B2: 697
        corticosterone methyl oxidase II: 6
    - Steroid Hydroxylases: 11
      - Cytochrome P-450 CYP11B2: 697
        corticosterone methyl oxidase II: 6
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Hemeproteins: 194
    - Cytochromes: 2196
      - Cytochrome P-450 Enzyme System: 5365
        Cytochrome P450 Family 11: 13
        Cytochrome P-450 CYP11B2: 697
        corticosterone methyl oxidase II: 6
        Steroid Hydroxylases: 11
        Cytochrome P-450 CYP11B2: 697
        corticosterone methyl oxidase II: 6

Experts

1.	Kaback, Michael: 1 article (10/2010)
2.	Lopatequi, Jean: 1 article (10/2010)
3.	Pariani, Mitchel: 1 article (10/2010)
4.	Portuges, Amin Riley: 1 article (10/2010)
5.	Quindipan, Cathy: 1 article (10/2010)
6.	Rimoin, David L: 1 article (10/2010)
7.	Salimpour-Davidov, Nilou: 1 article (10/2010)
8.	Canene-Adams, Kirstie: 1 article (02/2007)
9.	Erdman, John W: 1 article (02/2007)
10.	Lindshield, Brian L: 1 article (02/2007)

Related Diseases

1.	18-Hydroxylase deficiency 11/03/1988 - "The DNA fragment and the disease trait were inherited together in each family, demonstrating that CMO II deficiency is caused by a mutation in or very near the structural gene for P450c11 on chromosome 8. We conclude that the metabolic diseases of CMO II and 11-hydroxylase deficiency, which have distinct clinical symptoms, may be caused by different mutations in the single gene for a multifunctional enzyme." 01/01/1995 - "Nucleotide sequence analysis has indicated that the gene of CMO I deficient patients is completely inactivated by a frameshift to form a stop codon due to a 5-bp nucleotide deletion in exon 1. Sequence analysis of CYP11B2 of CMO II deficient patients has revealed two point mutations, CGG-->TGG (Arg181-->Trp) in exon 3 and GTG-->GCG (Val386-->Ala) in exon 7. CYP11B1, the gene for steroid 11 beta-hydroxylase (P45011 beta) which was previously postulated to be the target for CMO II deficiency, is not impaired in these two types of patients. "
2.	Autoimmune Polyendocrinopathies (Schmidt Syndrome) 10/01/2010 - "We screened for mutations responsible for four relatively frequent autosomal recessive conditions in Persian Jews in which effective interventions are available for each: Pseudocholinesterase deficiency (butyryl cholinesterase deficiency); Congenital hypoaldosteronism (corticosterone methyl oxidase II); Autoimmune polyendocrinopathy (autoimmune regulatory element); and Hereditary Inclusion Body myopathy. "
3.	Prostatic Neoplasms (Prostate Cancer) 02/15/2007 - "We term these metabolites "lycopenoids," which we believe may be produced from carotenoid monooxygenase (CMO) II, paralleling the production of retinoids from beta-carotene by CMO I. We present evidence suggesting that tomato carotenoid metabolites may be responsible for the reduced risk of prostate cancer seen in men consuming high levels of tomato products. "
4.	Neoplasms (Cancer) 07/21/2023 - "In this context, the main objective of this work was to evaluate in a real-life database: (i) the direct medical cost of monitoring the occurrence of AEs (CMO); (ii) the direct medical cost of managing an identified AE (CMN); and (iii) the total direct medical cost of monitoring and managing AEs (TMC), in quarterly periods from 0 to 24 months of the monitoring of cancer patients who used a PD-1 inhibitor from the perspective of the supplementary health system in Brazil. "
5.	Metabolic Diseases (Metabolic Disease) 11/03/1988 - "The DNA fragment and the disease trait were inherited together in each family, demonstrating that CMO II deficiency is caused by a mutation in or very near the structural gene for P450c11 on chromosome 8. We conclude that the metabolic diseases of CMO II and 11-hydroxylase deficiency, which have distinct clinical symptoms, may be caused by different mutations in the single gene for a multifunctional enzyme."

Related Drugs and Biologics

1.	Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)
2.	DNA (Deoxyribonucleic Acid)
3.	corticosterone methyl oxidase I
4.	Multifunctional Enzymes
5.	Cytochrome P-450 CYP11B2 (CYP11B2)
6.	beta Carotene (Betacarotene)
7.	Retinoids
8.	Nucleotides
9.	Mixed Function Oxygenases (Monooxygenases)
10.	Elements