|1.||Rose, Barbara: 1 article (02/2012)|
|2.||Manos, Jim: 1 article (02/2012)|
|3.||Harbour, Colin: 1 article (02/2012)|
|4.||Cordwell, Stuart J: 1 article (02/2012)|
|5.||Hare, Nathan J: 1 article (02/2012)|
|6.||Codd, Rachel: 1 article (02/2012)|
|7.||Soe, Cho Zin: 1 article (02/2012)|
|8.||Yaxley, Alice M: 1 article (09/2011)|
|9.||Song, Lijiang: 1 article (09/2011)|
|10.||Challis, Gregory L: 1 article (09/2011)|
05/01/2004 - "Pc715jfptA::tp persisted in rat lung infections in numbers similar to those of the parent strain, indicating that the ferric-ornibactin uptake system could compensate for the defect in ferric-pyochelin uptake in vivo. "
05/01/2004 - "Importance of the ornibactin and pyochelin siderophore transport systems in Burkholderia cenocepacia lung infections."
09/01/1988 - "Exogenously supplied pyochelin influenced the virulence of Pseudomonas cepacia pyochelin-negative strains in a chronic pulmonary infection model in rats. "
03/01/1986 - "Of the 22 strains which did not produce pyochelin, 13 were from patients with mild or moderate infections. "
03/01/1986 - "Of the 21 strains producing pyochelin, 18 were from patients with severe infections, 11 of which resulted in death. "
05/01/2007 - "In response to iron starvation, Pseudomonas aeruginosa produces the siderophore pyochelin. "
07/31/2001 - "During iron starvation the Gram-negative pathogenic bacterium Pseudomonas aeruginosa makes the nonribosomal peptide siderophore pyochelin by a four protein, 11 domain assembly line, involving a cascade of acyl-S-enzyme intermediates on the PchE and PchF subunits that are elongated, heterocyclized, reduced, and N-methylated before release. "
01/01/2004 - "These observations suggest that, under conditions of sulfur depletion, cysteine cannot be spared for production of pyochelin even under iron starvation conditions."
|3.||Cystic Fibrosis (Mucoviscidosis)
02/03/2012 - "Proteomics of Pseudomonas aeruginosa Australian epidemic strain 1 (AES-1) cultured under conditions mimicking the cystic fibrosis lung reveals increased iron acquisition via the siderophore pyochelin."
10/01/1996 - "We have found that interaction of bacteria with mucus from patients with cystic fibrosis results in marked induction of expression of several genes, including one that encodes a lipopolysaccharide biosynthetic enzyme, a gene for a protein responsible for uptake of the ferric pyochelin siderophore, and a new gene homologous with a class of iron-responsive repressors. "
02/01/1998 - "Sixty-one Burkholderia cepacia isolates from patients with cystic fibrosis (CF) and four plant isolates were screened for production of the siderophores salicylic acid (SA), pyochelin, cepabactin, and ornibactins and fingerprinted by a PCR-based randomly amplified polymorphic DNA (RAPD) method. "
|4.||Scabies (Sarcoptic Mange)
09/01/2011 - "scabies mutants, in which expression of the cluster is upregulated and which lack a key biosynthetic gene from the cluster, indicated that pyochelin is a product of the PBGC. "
09/01/2011 - "Genome sequencing of the plant pathogen Streptomyces scabies 87-22 revealed the presence of a putative pyochelin biosynthetic gene cluster (PBGC). "
09/01/2011 - "The plant pathogen Streptomyces scabies 87-22 has a functional pyochelin biosynthetic pathway that is regulated by TetR- and AfsR-family proteins."
|5.||Respiratory Tract Infections (Respiratory Tract Infection)
|4.||Salicylic Acid (2 Hydroxybenzoic Acid)
|7.||Staphylococcal Protein A (A, Protein)
|9.||Proteins (Proteins, Gene)
|10.||Peptide Hydrolases (Proteases)