alaproclate

specific 5-hydroxytryptamine uptake inhibitors; RN given refers to (DL)-isomer

Also Known As:

2-aminopropionic acid-1-(4-chlorophenyl)-2-methyl-2-propyl ester.HCl; A 23189; A-23189; D-alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride; L-alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester, hydrochloride; alaproclate hydrochloride; alaproclate hydrochloride, (D)-isomer; alaproclate hydrochloride, (L)-isomer; alaproclate hydrochloride, (R)-; alaproclate hydrochloride, (S)-; DL-Alanine, 2-(4-chlorophenyl)-1,1-dimethylethyl ester

Networked: 18 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Amino Acids: 30675
  - Alanine: 4133
    - alaproclate: 18

Experts

1.	Clark, T M: 1 article (11/2009)
2.	Hirschler, A N: 1 article (11/2009)
3.	Lawecki, J L: 1 article (11/2009)
4.	Samandu, T R: 1 article (11/2009)
5.	Shepherd, J J: 1 article (11/2009)

Related Diseases

1.	Dementia (Dementias) 01/01/1983 - "Alaproclate: a pharmacokinetic and biochemical study in patients with dementia of Alzheimer type." 02/01/1985 - "A double-blind parallel comparison of alaproclate and placebo was carried out in patients suffering from senile dementia of primary degenerative type, or multiinfarction dementia. " 01/01/1983 - "Alaproclate, a specific inhibitor of neuronal serotonin re-uptake, was given to 12 patients with dementia of Alzheimer type. "
2.	Tremor (Tremors) 08/01/1992 - "GEA 857, similarly to alaproclate (Ogren et al. 1985a & b), produced a dose-dependent, statistically significant (in the 5-20 mg/kg dose range) enhancement of the tremor response induced by all four cholinergic stimulants. " 01/01/1985 - "Both salivation and tremor could be fully blocked by atropine at any dose of the cholinergic stimulant and of alaproclate used. " 01/01/1985 - "Alaproclate, a nontricyclic 5-HT uptake inhibitor, when injected 30 min prior to the administration of the cholinergic agonist, produced a dose-dependent enhancement of tremor and salivation in both rats and mice. " 01/01/1985 - "Pretreatment with the 5-HT receptor antagonist metitepine completely blocked the enhancement of oxotremorine-induced tremor caused by alaproclate. " 01/01/1985 - "Atropine completely blocked the tremor caused by oxotremorine or physostigmine both in the presence and absence of alaproclate. "
3.	Shock 01/01/1984 - "Pretreatment with quipazine alone in a group of animals trained to a shock level which normally results in high levels of suppression was not sufficient to produce memory impairment, suggesting that quipazine was probably antagonizing the facilitative effects of alaproclate and zimeldine directly, rather than overriding the facilitation through an indirect action on retrieval in general. " 08/01/1986 - "In the saline-treated rats, acute treatment with all four drugs, desipramine, amitriptyline, iprindole and alaproclate, elevated the shock thresholds, whereas in 5-MeODMT-treated rats, desipramine and amitriptyline elevated shock thresholds. " 08/01/1986 - "The effect of chronic and acute oral or intraperitoneal treatment with the antidepressant drugs, desipramine, amitriptyline, alaproclate and iprindole, upon pain thresholds in the tail flick, hot plate and shock titration tests of nociception in saline- and 5-MeODMT-treated rats was studied. "
4.	Alzheimer Disease (Alzheimer's Disease) 02/01/1985 - "A double-blind comparison of alaproclate and placebo in the treatment of patients with senile dementia." 02/01/1985 - "A double-blind parallel comparison of alaproclate and placebo was carried out in patients suffering from senile dementia of primary degenerative type, or multiinfarction dementia. " 01/01/1984 - "Alaproclate, a new selective 5-HT uptake inhibitor with therapeutic potential in depression and senile dementia."
5.	Decapitation 05/01/1984 - "A single acute dose of desipramine (20 mg/kg) administered at various time intervals before decapitation (1 to 24 hours) had no effect on the PDC's nor did repeated treatment with the other compounds examined, alaproclate, citalopram, clomipramine, mianserin and zimeldine, have any effect upon the PDC latency. " 05/01/1984 - "The effects of repeated treatment of rats with the antidepressant or potential antidepressant agents alaproclate, citalopram, clomipramine, desipramine, imipramine, maprotiline, mianserin and zimeldine on the convulsions released by decapitation were examined. "

Related Drugs and Biologics

1.	Selective Serotonin Reuptake Inhibitors (Serotonin Reuptake Inhibitors)
2.	Serotonin (5 Hydroxytryptamine)
3.	Zimeldine (Zimelidine)
4.	Cholinergic Agents (Cholinergics)
5.	Oxotremorine
6.	Desipramine (Pertofrane)
7.	Muscarinic Agonists
8.	Citalopram
9.	Physostigmine
10.	Methiothepin

Related Therapies and Procedures

1.	Analgesia