diacerein

chelates with bivalent metals; a quinone which possesses redox properties; metabolized to active rhein; proposed mechanisms include inhibiting IL1 and metalloproteinases; called a slow acting symptomatic drug in osteoarthritis; no effect of cyclooxygenase;

Also Known As:

1,8-diacetoxy-3-carboxyanthraquinone; 2-anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-; 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic acid; 4,5-diacetoxyanthraquinone-2-carboxylic acid; 9,10-dihydro-4,5-dihydroxy-9,10-dioxo-2-anthroic acid, diacetate; AC-201; AC-203; Artrodar; Diora; Fisiodar; M-01AX21; M01AX21; SF-277; SF277; Verboril; Zondar; diacerhein; diacetyl-rhein; diacetylrhein; rhein diacetate

Networked: 260 relevant articles (45 outcomes, 71 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Dougados, M: 5 articles (02/2008 - 10/2001)
2.	Monfort, Jordi: 4 articles (12/2021 - 02/2016)
3.	Martel-Pelletier, Johanne: 4 articles (12/2020 - 04/2010)
4.	Pavelka, Karel: 4 articles (12/2020 - 12/2007)
5.	Pelletier, Jean-Pierre: 4 articles (12/2020 - 04/2010)
6.	Bauer, Johann W: 4 articles (10/2019 - 05/2013)
7.	Guadagnini, Dioze: 4 articles (01/2016 - 11/2011)
8.	Dhaneshwar, Suneela: 4 articles (01/2015 - 01/2013)
9.	Ahemad, Nafees: 3 articles (04/2021 - 04/2018)
10.	Ong, Chin Eng: 3 articles (04/2021 - 04/2018)

Related Diseases

1.	Osteoarthritis 07/02/2015 - "In the osteoarthritis diacerein-treated group the results showed an improvement with respect to the OA placebo group in all parameters, although the results were not statistically significant. " 07/12/2002 - "Diacerein has proved to be effective in the treatment of osteoarthritis. " 04/01/2001 - "Diacerein has proved to be effective in the treatment of osteoarthritis (OA). " 01/01/2001 - "Diacerein has proved to be effective in the treatment of osteoarthritis. " 07/01/1993 - "Cultured rabbit joint chondrocytes were exposed to diacerhein (DAR : ART 50, Negma, 10(-6) to 10(-4) M), which has proved effective and safe when given for two months for the treatment of osteoarthritis. "
2.	Pain (Aches) 03/01/2010 - "explicit statement about randomization to either diacerein or placebo, and co-primary outcomes being reduction in pain and improvement in function. " 09/11/2022 - "While diacerein is recommended for alleviating pain in OA patients, evidence for its effectiveness is inconsistent, possibly because studies have not targeted patients with an inflammatory phenotype. " 10/12/2016 - "This study did not demonstrate that coadministration of diacerein with pCGS improves pain and WOMAC score compared with pCGS monotherapy in patients with mild to moderate OA of the knee. " 02/10/2014 - "-quality evidence from six trials (1,283 participants) indicates that diacerein has a small beneficial effect on overall pain (measured on a 100 mm visual analogue scale) at three to 36 months (mean difference (MD) -8.65, 95% confidence interval (CI) -15.62 to -1.68), which is equivalent to a 9% pain reduction in the diacerein group (95% CI -16% to -2%) compared with the placebo group. " 03/01/2010 - "Six trials (seven sub-studies; 1533 patients) contributed to the meta-analysis, revealing a large degree of inconsistency among the trials (I(2)=56%) in regard to pain reduction: the combined ES was -0.24 [95% confidence intervals (CI): -0.39 to -0.08, P=0.003], favouring diacerein. "
3.	Knee Osteoarthritis 12/01/2007 - "To determine whether the efficacy of diacerein persists at 2 months after the end of a 3-month treatment period, compared with placebo, in patients with painful knee osteoarthritis (OA). " 08/01/2023 - "(2007), The efficacy and safety of diacerein in the treatment of painful osteoarthritis of the knee: A randomized, multicenter, double-blind, placebo-controlled study with primary end points at two months after the end of a three-month treatment period. " 07/20/2023 - "Hence, this study attempted to investigate the efficacy and safety of Diacerein in the management of knee osteoarthritis. " 11/18/2022 - "To estimate the symptomatic efficacy, residual effect and safety of diacerein in the treatment of knee osteoarthritis, using a meta-analysis of published randomized controlled trials (RCTs). " 11/18/2022 - "Efficacy, residual effectiveness and safety of diacerein in the treatment of knee osteoarthritis: A meta-analysis of randomized placebo-controlled trials."
4.	Inflammation (Inflammations) 01/01/2018 - "Inhibition of inflammation using diacerein markedly improved renal function in endotoxemic acute kidney injured mice." 01/01/2023 - "Diacerein pretreatment has the ability to restore the PF damaging effect, proved by the reduction of the oxidative stress and lung tissue inflammation via downregulation of TLR4/NF-κB signaling pathway together with the restoration of TGF-β level and improvement of the histopathological and immunohistochemical study findings in the lung tissue. " 02/21/2023 - "Our results demonstrated that diacerein significantly alleviated the psoriasiform-like skin inflammation over a 7-day period. " 11/01/2022 - "Diacerein alleviates Ang II-induced cardiac inflammation and remodeling by inhibiting the MAPKs/c-Myc pathway." 10/01/2022 - "Yet, the benefits of using the antiarthritic agent diacetylrhein to counteract inflammation in UC are still obscure. "
5.	Type 2 Diabetes Mellitus (MODY) 03/04/2022 - "We conducted this study to determine the efficacy of low-dose diacerein in improving glycaemic control in type 2 diabetes mellitus (T2DM) patients with inadequate glycaemic control and to identify the metabolic determinants for such improvement. " 07/01/2011 - "Insulin secretion increased and metabolic control improved after diacerein administration in drug-naïve patients with type 2 diabetes." 01/01/2021 - "A systematic review and meta-analysis of clinical trials were undertaken to evaluate the effect of diacerein intake on cardiometabolic profiles in patients with type 2 diabetes mellitus (T2DM). " 01/01/2017 - "Although further studies are needed, our findings clearly provide support to the use of diacerein in the clinical management of subjects with type 2 diabetes." 01/01/2017 - "The aim of this systematic review and meta-analysis of randomized controlled trials (RCTs) is to examine the effect and safety of diacerein in patients with type 2 diabetes. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Intra-Articular Injections
3.	Ligation
4.	Glycemic Control
5.	Aftercare (After-Treatment)