RN given refers to parent cpd
Also Known As:
2,6-DAT; 2,6-diaminotoluene dihydrochloride; 2,6-toluenediamine; 1,3-Benzenediamine, 2-methyl-
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Bio-Agent Context: Research Results
|1. ||Neoplasms (Cancer)
- "However, the differences in the results of chronic rodent carcinogen bioassays using these two compounds are significant, in that 2,4-DAT is a potent hepatocarcinogen, whereas 2,6-DAT does not produce an increased incidence of tumors in rats or mice at similar doses.
- "2,4-DAT is a potent hepatocarcinogen whereas 2,6-DAT failed to produce an increased incidence of tumors in any tissue even when administered at a dose higher than that of 2,4-DAT.
- "Both compounds are rapidly absorbed after oral administration and are equally mutagenic in the Ames test; however, 2,4-DAT is a potent hepatocarcinogen, whereas 2,6-DAT does not produce an increased incidence of tumors in rats or mice at similar doses.
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