eupaformosanin

inhibits deoxyribonucleic acid synthesis in Ehrlich ascites cells; structure given in first source; RN given refers to (3AR-(3AR*,4R*(E),6E,9R*,10Z,11AR*))-isomer

Also Known As:

eupaformosanin, (3aR-(3aR*,4R*(E)),6E,9S*,10Z,11aR*)-isomer; 4-hydroxy-2-(hydroxymethyl)-, 9-(acetyloxy)-2,3,3a,4,5,8,9,11a-octahydro- 6,10-dimethyl-3-methylene-2-oxocyclodeca(b)furan-4-yl ester, (3aR-(3aR*,4R*(E),6E,9R*,10Z, 11aR*))-2-butenoic acid

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - eupaformosanin: 2

Experts

1.	Guan, Jiaqi: 1 article (06/2022)
2.	Hu, Hongtao: 1 article (06/2022)
3.	Wei, Yingying: 1 article (06/2022)
4.	Yang, Bo: 1 article (06/2022)
5.	Zhao, Huajun: 1 article (06/2022)
6.	Zhu, Zhihui: 1 article (06/2022)

Related Diseases

1.	Triple Negative Breast Neoplasms 06/05/2022 - "Here, we showed that eupaformosanin (Eup), a natural compound isolated from Eupatorium cannabinum Linn., significantly inhibited the viability of triple-negative breast cancer (TNBC) cells. " 06/05/2022 - "Eupaformosanin induces apoptosis and ferroptosis through ubiquitination of mutant p53 in triple-negative breast cancer."
2.	Ascites 03/01/1980 - "The major effect of eupaformosanin as an antineoplastic agent on Ehrlich ascites cell metabolism was to inhibit deoxyribonucleic acid synthesis, specifically at deoxyribonucleic acid polymerase and thymidylate synthetase enzymatic sites. " 03/01/1980 - "Antitumor agents XLI: Effects of eupaformosanin on nucleic acid, protein, and anaerobic and aerobic glycolytic metabolism of Ehrlich ascites cells."

Related Drugs and Biologics

1.	Thymidylate Synthase
2.	Proteins (Proteins, Gene)
3.	Nucleic Acids
4.	DNA (Deoxyribonucleic Acid)
5.	Antineoplastic Agents (Antineoplastics)