Ubiquinone Q1

interacts with iron atom to form acceptor quinone complex

Also Known As:

CoQ1; coenzyme Q1; coenzyme Q5; ubiquinone 5; 2,5-cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-6-(3-methyl-2-butenyl)-

Networked: 12 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Quinones: 434
  - Benzoquinones: 25
    - Ubiquinone: 788
      - Ubiquinone Q1: 12
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Ubiquinone: 788
    - Ubiquinone Q1: 12

Experts

1.	Audi, Said H: 2 articles (10/2008 - 09/2007)
2.	Bongard, Robert D: 2 articles (10/2008 - 09/2007)
3.	Krenz, Gary S: 2 articles (10/2008 - 09/2007)
4.	Merker, Marilyn P: 2 articles (10/2008 - 09/2007)
5.	Dhingra, Rimpy: 1 article (11/2021)
6.	Khatua, Tarak N: 1 article (11/2021)
7.	Kirshenbaum, Lorrie A: 1 article (11/2021)
8.	Margulets, Victoria: 1 article (11/2021)
9.	Martino, Tami A: 1 article (11/2021)
10.	Posen, Illana: 1 article (11/2021)

Related Diseases

1.	Ischemia 03/01/2015 - "In this study, the effects of delphinidin 3-O-glucoside (Dp3G), cyanidin 3-O-glucoside (Cy3G) and pelargonidin 3-O-glucoside (Pg3G) on the activity of complex I of the mitochondrial respiratory chain were studied in mitochondria isolated from normal rat hearts and rat hearts subjected to ischemia for 45 min. Cy3G and Dp3G increased the activity of complex I, measured in the presence or absence of coenzyme Q1 (CoQ1 ), in ischemia-damaged mitochondria, whereas in nonischemic mitochondria the effect was observed only in the absence of CoQ1 . " 11/01/2021 - ": ARNTL/BMAL1: aryl hydrocarbon receptor nuclear translocator-like; ATG14: autophagy related 14; ATG7: autophagy related 7; ATP: adenosine triphosphate; BCA: bovine serum albumin; BECN1: beclin 1, autophagy related; bHLH: basic helix- loop-helix; CLOCK: circadian locomotor output cycles kaput; CMV: cytomegalovirus; COQ5: coenzyme Q5 methyltransferase; CQ: chloroquine; CRY1: cryptochrome 1 (photolyase-like); DNM1L/DRP1: dynamin 1-like; EF: ejection fraction; EM: electron microscopy; FS: fractional shortening; GFP: green fluorescent protein; HPX: hypoxia; i.p.: intraperitoneal; I-R: ischemia-reperfusion; LAD: left anterior descending; LVIDd: left ventricular internal diameter diastolic; LVIDs: left ventricular internal diameter systolic; MAP1LC3/LC3: microtubule-associated protein 1 light chain 3; MFN2: mitofusin 2; MI: myocardial infarction; mPTP: mitochondrial permeability transition pore; NDUFA4: Ndufa4, mitochondrial complex associated; NDUFA8: NADH: ubiquinone oxidoreductase subunit A8; NMX: normoxia; OCR: oxygen consumption rate; OPA1: OPA1, mitochondrial dynamin like GTPase; OXPHOS: oxidative phosphorylation; PBS: phosphate-buffered saline; PER1: period circadian clock 1; PPARGC1A/PGC-1α: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; qPCR: quantitative real-time PCR; RAB7A: RAB7, member RAS oncogene family; ROS: reactive oxygen species; RT: room temperature; shRNA: short hairpin RNA; siRNA: small interfering RNA; TFAM: transcription factor A, mitochondrial; TFEB: transcription factor EB; TMRM: tetra-methylrhodamine methyl ester perchlorate; WT: wild -type; ZT: zeitgeber time."
2.	Hyperoxia 10/01/2008 - "Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia." 09/01/2007 - "Role of mitochondrial electron transport complex I in coenzyme Q1 reduction by intact pulmonary arterial endothelial cells and the effect of hyperoxia."
3.	Parkinson Disease (Parkinson's Disease) 12/01/1990 - "Anatomic and disease specificity of NADH CoQ1 reductase (complex I) deficiency in Parkinson's disease." 01/01/1994 - "Rotenone-sensitive NADH coenzyme Q1 reductase activity (complex I) was reduced to levels intermediate between those in control subjects and those in patients with overt Parkinson's disease, but this change did not reach statistical significance. "
4.	Mitochondrial Diseases (Mitochondrial Disease) 09/01/2015 - "This reduction is diminished upon in vitro CoQ1 supplementation, indicating that CoQ10 deficit is the underlying cause for the mitochondrial dysfunction. "
5.	MELAS Syndrome (Syndrome, MELAS) 03/31/2011 - "The observed cytosolic-mitochondrial shuttling of idebenone and CoQ1 was also associated with reduced lactate production by cybrid cells from mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes (MELAS) patients. "

Related Drugs and Biologics

1.	Ubiquinone Q1
2.	cyanidin-3-O-beta-glucopyranoside
3.	pelargonidin
4.	delphinidin
5.	Electron Transport Complex I (NADH-CoQ Reductase)
6.	Oxidoreductases (Dehydrogenase)
7.	NAD (NADH)
8.	Cryptochromes
9.	Aryl Hydrocarbon Receptor Nuclear Translocator
10.	Green Fluorescent Proteins