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3-methoxybenzamide

inhibitor of poly ADP ribose synthetase

Also Known As:

m-methoxybenzamide; benzamide, 3-methoxy-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133

Experts

1.	Baker, Nicola: 1 article (01/2013)
2.	Bennett, James M: 1 article (01/2013)
3.	Berry, Joanne: 1 article (01/2013)
4.	Collins, Ian: 1 article (01/2013)
5.	Czaplewski, Lloyd G: 1 article (01/2013)
6.	Haydon, David J: 1 article (01/2013)
7.	Logan, Alastair: 1 article (01/2013)
8.	Macdonald, Rebecca: 1 article (01/2013)
9.	Macleod, Leanne: 1 article (01/2013)
10.	Mitchell, Jeffrey P: 1 article (01/2013)

Related Diseases

1.	Xeroderma Pigmentosum (Kaposi's Disease) 01/01/1986 - "[Spontaneous and induced sister chromatid exchanges in the blood lymphocytes of healthy persons and of xeroderma pigmentosum patients exposed to the inhibitors of DNA repair and replication caffeine, 3-methoxybenzamide and novobiocin]."
2.	Staphylococcal Infections 01/01/2013 - "aureus cells recovered from infected thighs, equivalent to 3.68 log units, than in those recovered from controls was achieved using a succinate prodrug of compound 1, which was designated compound 2. In summary, optimized derivatives of 3-methoxybenzamide may yield a first-in-class FtsZ inhibitor for the treatment of antibiotic-resistant staphylococcal infections."
3.	Yoshida Sarcoma 02/01/1982 - "The sensitivities (Do-values) of the cytotoxic effect of MNU on four rodent cell lines were: mouse L1210, 0.07 mM; rat Yoshida sarcoma, 0.52 mM; Chinese hamster V79A, 0.70 mM and the UV sensitive, X-ray sensitive V79/79, 0.35 mM. The abilities of maximum non-toxic doses of the poly-(ADP-ribose) polymerase inhibitors, 5-methyl nicotinamide (5MeN), 3-methoxybenzamide (3MBA) and caffeine to potentiate this cytotoxicity and that of UV light in V79A and V79/79 was measured. "
4.	Neoplasms (Cancer) 10/01/1990 - "The effects of inhibitors of poly(ADP-ribose)polymerase, 3-aminobenzamide (ABA), luminol and 3-methoxybenzamide (MBA) on the rat liver tumor promotion activity of phenobarbital (PB) were assessed. "
5.	Hyperthermia 11/01/1983 - "Two inhibitors of poly(ADP-ribose) synthetase, 5-methylnicotinamide and m-methoxybenzamide, enhanced the cytotoxicity of 42 degrees C and 45 degrees C hyperthermia in cultured Chinese hamster V79 cells. "

Related Drugs and Biologics

1.	Caffeine (No Doz)
2.	Poly(ADP-ribose) Polymerase Inhibitors
3.	Succinic Acid (Succinate)
4.	Prodrugs
5.	Poly Adenosine Diphosphate Ribose
6.	Phenobarbital (Luminal)
7.	Novobiocin (Streptonivicin)
8.	Niacinamide (Nicotinamide)
9.	Luminol
10.	Ligases (Synthetase)