ONO 1206

tested as antianginal agent

Also Known As:

17-S-methyl-omega-homo-trans-delta(2)-PGE1; 17-S-methyl-omega-homo-trans-delta(2)-prostaglandin E1; ONO-1206; OP 1206; OP-1206; Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11alpha,13E,15S,17S)-

Networked: 14 relevant articles (4 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Fatty Acids: 27405
  - Unsaturated Fatty Acids: 8236
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins E: 2673
        Alprostadil: 3107
        ONO 1206: 14
    - Monounsaturated Fatty Acids: 676
      - Alprostadil: 3107
        ONO 1206: 14
Biological Factors: 2472
- Inflammation Mediators: 1113
  - Autacoids: 276
    - Eicosanoids: 3262
      - Prostaglandins: 17100
        Prostaglandins E: 2673
        Alprostadil: 3107
        ONO 1206: 14

Experts

1.	Akimaru, Shinji: 3 articles (10/2003 - 06/2002)
2.	Katsube, Nobuo: 3 articles (10/2003 - 06/2002)
3.	Maegawa, Hitoshi: 3 articles (10/2003 - 06/2002)
4.	Marsala, Martin: 3 articles (10/2003 - 06/2002)
5.	Nakai, Katsuhiko: 3 articles (10/2003 - 06/2002)
6.	Takenobu, Yoshifumi: 3 articles (10/2003 - 06/2002)
7.	Takimizu, Hideyuki: 3 articles (10/2003 - 06/2002)
8.	Ito, Hidenori: 2 articles (10/2003 - 07/2003)
9.	Gao, Feng: 2 articles (12/2002 - 07/2002)
10.	Horie, Toshiharu: 2 articles (12/2002 - 07/2002)

Related Diseases

1.	Spinal Stenosis (Stenosis, Spinal) 07/01/2003 - "These data suggest that the therapeutic effect of OP-1206 alpha-CD is primarily mediated by the improved local SCBF at the territory of spinal stenosis and not due to improvement of peripheral perfusion and/or antiplatelet activity." 10/01/2003 - "To determine whether the OP-1206 alpha-CD in combination with loxoprofen-Na could induce a greater therapeutical effect on walking dysfunction and spinal cord blood flow (SCBF) than OP-1206 alpha-CD treatment alone after chronic spinal stenosis in the rat. " 10/01/2003 - "An orally active prostaglandin E1 analogue, OP-1206 alpha-CD improves walking dysfunction in the rat spinal stenosis model. " 06/01/2002 - "OP-1206 alpha-CD was administered orally bid for 11 days from postoperative Day 3. In Control nontreated rats, a significant walking dysfunction was observed from Day 1 after the induction of spinal stenosis and persisted for 14 days when compared with the Sham-Operated group. " 06/01/2002 - "These data show that oral treatment with OP-1206 alpha-CD is effective in improving walking dysfunction induced by spinal canal stenosis, and this therapeutic effect is likely mediated by improved SCBF at the territory of spinal stenosis. "
2.	Hypotension (Low Blood Pressure) 09/01/1980 - "OP 1206 given orally at more than 100 micrograms/kg relieved vasopressin-induced ST depression of rat electrocardiogram (ECG), an animal model of angina pectoris, concomitant with slight hypotension. "
3.	Diabetic Neuropathies (Diabetic Neuropathy) 06/01/1991 - "The results suggest that OP-1206 ameliorates a decrease in nerve Na(+)-K(+)-ATPase activity without any effect on nerve myo-inositol level and that the compound may be not only a potent therapeutic agent for the treatment of diabetic neuropathy but also a useful research tool to investigate the mechanism of nerve Na(+)-K(+)-ATPase activity regulation." 06/01/1991 - "An oral prostaglandin E1 (PGE1) analogue, OP-1206.alpha-CD, was given to rats with streptozocin (STZ)-induced diabetes to examine the therapeutic effects of OP-1206 on short-term and long-term diabetic neuropathy and its action mechanism with special reference to nerve Na(+)-K(+)-ATPase activity. "
4.	Pathologic Constriction (Stenosis) 06/01/2002 - "These data show that oral treatment with OP-1206 alpha-CD is effective in improving walking dysfunction induced by spinal canal stenosis, and this therapeutic effect is likely mediated by improved SCBF at the territory of spinal stenosis. "
5.	Angina Pectoris 09/01/1980 - "OP 1206 given orally at more than 100 micrograms/kg relieved vasopressin-induced ST depression of rat electrocardiogram (ECG), an animal model of angina pectoris, concomitant with slight hypotension. "

Related Drugs and Biologics

1.	Therapeutic Uses
2.	Vasopressins (Vasopressin)
3.	Inositol (Myoinositol)
4.	Adenosine Triphosphatases (ATPase)
5.	Alprostadil (Muse)
6.	Prostaglandins
7.	Reactive Oxygen Species (Oxygen Radicals)
8.	Methotrexate (Mexate)
9.	Antineoplastic Agents (Antineoplastics)
10.	Oxygen (Dioxygen)

Related Therapies and Procedures

1.	Oral Administration
2.	Therapeutics
3.	Oxygen Inhalation Therapy