15- hydroperoxy- 5,8,11,13- eicosatetraenoic acid

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7 relevant articles (0 outcomes, 1 trials/studies) found for this Bio-Agent

Description: RN given refers to cpd without isomeric designation; (S-(E,Z,Z,Z))-isomer caused dose-dependent constriction of cat coronary arteries; structure in first source

Also Known As:

14,15-epoxyarachidonic acid; 15-HPAA; 15-HPEA; 15-HPETE; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (E,Z,Z,Z)-isomer; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (S)-(E,Z,Z,Z)-isomer; 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (Z,Z,Z,Z)-isomer; 15-hydroperoxy-5,8,11,14-eicosatetraenoic acid; 15-hydroperoxyarachidonic acid; arachidonic acid 15-hydroperoxide; 5,8,11,13-eicosatetraenoic acid, 15-hydroperoxy-

Bio-Agent Context: Research Results

Related Diseases

1.	Hyperalgesia 09/01/1997 - "4. The results of the present study suggest that the release of 15-HPETE into the airways could contribute to sensitization of afferent nerve endings analogous to the hyperalgesia induced by this mediator in skin." Order ALL the reference details at left...
2.	Thrombosis (Thrombus) 01/01/1980 - "The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis." 12/01/1979 - "The effect of 15-hydroperoxyarachidonic acid on the arterial wall during ADP-induced local platelet thrombosis." Order ALL the reference details at left...
3.	Adhesions 02/01/1997 - "The 15-HPETE was found to inhibit the TNF-alpha-induced increase in adhesion molecule expression in the early stage of the incubation, but expression returned to normal after 18 hours" 04/28/1983 - "Pre-treatment of aortic segments with 15-HPETE, a selective inhibitor of PGI2-synthetase, abolished the inhibitory effect of dazoxiben on adhesion" 02/01/1997 - "The data show that human umbilical vein endothelial cells, pretreated with these fatty acids, have a reduced ability to be stimulated by tumor necrosis factor-alpha (TNF-alpha) for enhanced neutrophil and monocyte adhesion; the order of inhibitory activity being 15-HPETE > 15-HETE > 20:4 (n-6)" Order ALL the reference details at left...
4.	Atherosclerosis (Atheroma) 02/01/1990 - "The interaction between platelets and endothelium was augmented in RbAs from animals with atherosclerosis and in RbAs pretreated with aspirin (110 microM) or 15-HPETE (150 microM) or by the enzymatic system generating oxygen free radicals (xanthine:xanthine oxidase - 100 microM: 0.1 U/ml)" Order ALL the reference details at left...
5.	Hypocapnia 10/01/1984 - "15-HPETE induced arteriolar dilation during application, sustained dilation 1 h after washout, and reduced responsiveness to the vasoconstrictive effects of hypocapnia" Order ALL the reference details at left...

Related Drugs and Biologics

1.	Xanthine
2.	Xanthine Oxidase
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Oxygen
5.	Free Radicals
6.	Fatty Acids (Saturated Fatty Acids)
7.	Aspirin (Acetylsalicylic Acid)
8.	Adenosine Diphosphate (ADP)
9.	dazoxiben
10.	15-hydroxy-5,8,11,13-eicosatetraenoic acid

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