N-amyl-N-methylnitrosamine

05/01/1985 - "[Sequential histochemical studies of the esophageal carcinoma in rats induced by N-methyl-N-amylnitrosamine]."
06/01/1982 - "Sequential morphological studies of the esophageal carcinoma of rats induced by N-methyl-N-amylnitrosamine."
10/01/1981 - "[Sequential morphological studies of the esophageal carcinoma of rats induced by N-methyl-N-amylnitrosamine (author's transl)]."
02/01/1980 - "Esophageal carcinoma in rats induced by N-amyl-N-methylnitrosamine."
04/01/1988 - "Cytophotometric DNA analysis of esophageal dysplasia and carcinoma induced in rats by N-methyl-N-amylnitrosamine."

01/01/1988 - "Light and electron microscopic and autoradiographic studies on N-methyl-N-amylnitrosamine-induced rat esophageal carcinogenesis."
01/15/2005 - "To understand more about the molecular mechanisms during carcinogenesis, we produced esophageal neoplastic lesions by administering N-amyl-N-methylnitrosamine and 12-O-tetradecanoylphorbol-13-acetate to rats. "
09/01/2002 - "Elevated susceptibility of the p53 knockout mouse esophagus to methyl-N-amylnitrosamine carcinogenesis."
11/11/1991 - "The role of alkaline reflux in esophageal carcinogenesis induced by N-amyl-N-methylnitrosamine in rats."
11/01/1987 - "Enhancement of esophageal carcinogenesis induced in rats by N-amyl-N-methylnitrosamine in the presence of 12-O-tetradecanoylphorbol-13-acetate."

09/01/2002 - "In this study we investigated the susceptibility of p53 nullizygous (-/-), heterozygous (+/-) and wild-type (+/+) mice to methyl-N-amylnitrosamine (MNAN), which specifically induces esophageal tumors in mice and rats. "
09/01/1979 - "Hence, a 6- or 12-week treatment schedule was adequate for inducing esophageal tumors and could be used for studies on agents modifying esophageal tumor induction by methyl-n-amylnitrosamine."
07/01/2007 - "Upon methyl-N-amylnitrosamine (MNAN) treatment, 70% Brca1 mutant mice developed tumors within 4 months whereas only 14% control animals developed tumor at the same period of the time. "
05/15/1998 - "N-Amyl-N-methylnitrosamine (AMN) which specifically induces esophageal tumors in mice and rats was given to three mutant mouse strains, i.e. "
10/22/1996 - "We examined the toxicity and carcinogenicity in rodents of methyl-n-amylnitrosamine (MNAN), multiple doses of which are known to induce esophageal and nasal tumors in rats. "

12/01/1980 - "[Induction of esophageal cancer in rats by different doses of N-methyl-N-amylnitrosamine (author's transl)]."
05/01/1990 - "In experimental animal studies, 47 esophageal cancers were induced in male Wistar rats by oral administration of N-amyl-N-methylnitrosamine (AMN) and were analysed in the study of ploidy patterns. "
01/01/1999 - "Methyl-n-amylnitrosamine (MNAN) induces esophageal cancer in rats, probably involving activation by cytochromes P450. "
05/15/1998 - "High incidence of esophageal cancer in esophageal achalasia by the oral administration of N-amyl-N-methylnitrosamine and its prevention by nicardipine hydrochloride in mice."
11/01/1987 - "The effects of 12-O-tetradecanoylphorbol-13-acetate (TPA), a tumor-promoting phorbol diester, were determined with regard to the induction of esophageal cancer in Wistar rats following a low-dose initial administration of the esophageal carcinogen N-amyl-N-methylnitrosamine [(AMN) CAS: 13256-07-0]. "

09/01/1990 - "These findings demonstrate that NMBzA and N-nitrosomethylamylamine and probably related methylalkylnitrosamines are effectively bioactivated in premalignant lesions, indicating that during chronic exposure papillomas can acquire additional mutations that are likely to play a major role in tumour progression."
09/01/1979 - "After 6 weekly methyl-n-amylnitrosamine injections of 25 mg/kg or 12 weekly injections of either 12.5 or 25 mg/kg, the incidence of esophageal squamous cell papillomas was 85 to 100% and that of esophageal squamous cell carcinomas was 40 to 65%. "