cephamycin C

produced from O-carbamoyldeacetylcephalosporin in C by cell-free extracts of Streptomyces clavuligerus; RN given refers to cpd without isomeric designation; structure given in first source

Also Known As:

A 16886B; A-16886B; A16886B; cephamycin C sodium; cephamycin C, (6R)-isomer; cephamycin C, (6R-(6alpha,7alpha,7(R*)))-isomer; cephamycin C, (6R-(6alpha,7alpha,7(S*)))-isomer; cephamycin C, monosodium salt; cephamycin C, sodium salt; 5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 3-(((aminocarbonyl)oxy)methyl)-7-(((5R)-5-amino-5-carboxy-1-oxopentyl)amino)-7-methoxy-8-oxo-, (6R,7S)-

Networked: 4 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jin, Wook: 1 article (10/2004)
2.	Kang, Sung Gyun: 1 article (10/2004)
3.	Kim, Hyo Kyung: 1 article (10/2004)
4.	Kim, Jae Young: 1 article (10/2004)
5.	Lee, Kye Joon: 1 article (10/2004)
6.	Lee, Sang Hee: 1 article (10/2004)

Related Diseases

1.	Diarrhea 09/01/1980 - "Thus, cephamycin C was highly effective in restoring the calves and piglets to good health by eliminating diarrhea and reducing mortality." 09/01/1980 - "When eight doses of cephamycin C were given therapeutically starting at 6 h post-inoculation, mortality was reduced from 79 to 23% (P < 0.02), and diarrhea was eliminated in the surviving medicated piglets by 4 days post-inoculation. " 09/01/1980 - "In colostrum-fed calves infected with Escherichia coli strain B44, cephamycin C administered by gavage at 31.3 to 1,000 mg per calf (0.75 to 24 mg/kg) twice a day for 6 days starting at 20 h post-inoculation eliminated the diarrhea and reduced the mortality from 90% in infected, nonmedicated calves to 14% in infected, medicated calves (P < 0.01). " 09/01/1980 - "In infected suckling piglets, cephamycin C administered therapeutically by gavage at 12.5 mg per piglet twice a day for 3 days starting at 6 h post-inoculation, diarrhea and mortality were reduced (P < 0.05): infected, nonmedicated piglets had 87% diarrhea and 75% mortality, whereas infected, medicated piglets had 25% diarrhea and 31% mortality. " 09/01/1980 - "coli strain P155 and housed in cages, cephamycin C administered prophylactically by gavage at 12.5 mg per piglet (10.4 mg/kg) twice a day for 4 days completely prevented both diarrhea and mortality, whereas nonmedicated piglets had 100% diarrhea and all died. "
2.	Weight Gain 04/01/1981 - "The weight gain and feed efficiency of the infected pigs treated with the 112.5-mg dose of cephamycin C and the noninfected, nonmedicated control pigs were equivalent."
3.	Starvation 10/19/2004 - "The changes in the cephamycin C production by disruption of the relA and rsh genes are presumably associated with the consequent ability of the mutants to accumulate (p)ppGpp under nutrient starvation. "
4.	Salmonella Infections (Salmonellosis) 04/01/1981 - "Cephamycin C treatment of induced swine salmonellosis."
5.	Cholera 01/01/2022 - "KEGG module analysis revealed 48 gut microbiome functional modules significantly (p < 0.05) associated with CMC, including Vibrio cholerae pathogenicity signature, cholera toxins (p = 9.52e-04), and cephamycin C biosynthesis module (p = 0.0057), among others. "

Related Drugs and Biologics

1.	Guanosine Pentaphosphate