beta-carboline-3-carboxylic acid ethyl ester

isolated from brain tissue & urine; extremely potent displacer of diazepam from brain benzodiazepam receptors; structure in first source

Also Known As:

3-carboethoxy-beta carboline; BC-3-CAEE; beta-CCE; ethyl-beta-carboline-3-carboxylate; pyrido(3,4-b)indole-3-carboxylic acid ethyl ester; 9H-Pyrido(3,4-b)indole-3-carboxylic acid, ethyl ester

Networked: 14 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - Carbolines: 283
      - beta-carboline-3-carboxylic acid ethyl ester: 14
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - Indole Alkaloids: 200
        Carbolines: 283
        beta-carboline-3-carboxylic acid ethyl ester: 14
  - 3-Ring Heterocyclic Compounds
    - Carbolines: 283
      - beta-carboline-3-carboxylic acid ethyl ester: 14

Related Diseases

1.	Seizures (Absence Seizure) 08/01/1999 - "The BZ full inverse agonist dimethoxy-4-ethyl-beta-carboline-3-carboxylate also did not engender > or = 80% beta-CCE-lever responding up to doses that suppressed response rate and produced seizures in some animals. " 06/12/1981 - "Beta-CCE, at very low doses ranging from 8 to 100 microgram/kg (i.v.), induced a reactivation of the limbic focus and photomyoclonic and generalized seizures in photosensitive and non-photosensitive baboons. " 05/23/1983 - "These observations suggest that the electroencephalographic seizures elicited by beta-CCE are mediated via an interaction with benzodiazepine receptors. " 05/23/1983 - "Pretreatment of animals with the benzodiazepine receptor antagonists CGS 8216 prevented the electroencephalographic seizures elicited by beta-CCE. " 05/23/1983 - "3-carboethoxy-beta-carboline (beta-CCE) elicits electroencephalographic seizures in rats: reversal by the benzodiazepine antagonist CGS 8216."
2.	Shock 04/08/1985 - "Low doses of beta-CCE (0.03 - 0.3 mg/kg, i.m.) increased responding of monkeys maintained by shock presentation, but did not affect food-maintained responding; higher doses of beta-CCE decreased responding under both schedules. " 02/01/1986 - "When administered alone, beta-CCE produced effects opposite those of zopiclone and the benzodiazepines by decreasing responding maintained by food and increasing shock-maintained responding.(ABSTRACT TRUNCATED AT 250 WORDS)" 04/01/1992 - "Histamine (17.8-100 micrograms/kg/inj), I-nicotine (32 micrograms/kg/inj) and beta-CCE (10-56 micrograms/kg/inj), but not cocaine (10.0-100.0 micrograms/kg/inj), produced a dose-related selective suppression of responding similar to that obtained with electric shock, suggesting that the drugs were functioning as punishers. "
3.	Reflex Epilepsy (Photosensitive Epilepsy) 06/12/1981 - "beta-Carboline-3-carboxylic acid ethyl ester (beta-CCE) was tested on two models of epilepsy in the baboon: kainic acid-induced limbic status epilepticus and photosensitive epilepsy. "
4.	Vomiting 09/17/1991 - "The agonist midazolam produced sedative effects, the antagonist flumazenil produced no behavioral effects, the inverse agonist FG7142 produced tremor and the inverse agonist 3-carboethoxy-beta-carboline hydrochloride (beta CCE) produced tremor, vomiting, jerks and seizures. " 09/17/1991 - "Compared to the non-dependent condition, in the diazepam-dependent condition (baboons maintained on 20 mg/kg per day diazepam) and withdrawn condition (dependent baboons tested during withdrawal), midazolam produced decreased sedative effects, flumazenil produced increased effects (i.e., tremor, vomiting and jerks), and beta CCE produced increased frequency of seizures. "
5.	Tremor (Tremors) 09/17/1991 - "The agonist midazolam produced sedative effects, the antagonist flumazenil produced no behavioral effects, the inverse agonist FG7142 produced tremor and the inverse agonist 3-carboethoxy-beta-carboline hydrochloride (beta CCE) produced tremor, vomiting, jerks and seizures. " 09/17/1991 - "Compared to the non-dependent condition, in the diazepam-dependent condition (baboons maintained on 20 mg/kg per day diazepam) and withdrawn condition (dependent baboons tested during withdrawal), midazolam produced decreased sedative effects, flumazenil produced increased effects (i.e., tremor, vomiting and jerks), and beta CCE produced increased frequency of seizures. "

Related Drugs and Biologics

1.	Benzodiazepines
2.	GABA-A Receptors (GABA(A) Receptor)
3.	Flumazenil (Romazicon)
4.	Diazepam (Valium)
5.	2- phenylpyrazolo(4,3- c)quinolin- 3(5H)- one
6.	beta-carboline-3-carboxylic acid ethyl ester
7.	Triiodothyronine (Liothyronine)
8.	Nicotine
9.	Midazolam (Versed)
10.	Methoxyflurane (Penthrane)

Related Therapies and Procedures

1.	Anesthesia