asebotoxin III

isolated from Pieris japonica; RN given refers to above cpd

Also Known As:

acebotoxin III; asebotoxin I; grayanotoxane-5,610,14,16-pentol, 2,3-epoxy-,14-(2-hydroxypropanoate), (2beta,3beta,6beta,14R)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

1.	Edema (Dropsy) 02/01/1983 - "[Pharmacological studies on the mechanisms of asebotoxin III-induced centrogenic pulmonary hemorrhagic edema in guinea pigs]."
2.	Ischemia 01/01/1998 - "These triphasic changes during ischemia were affected by various agents that affect the cytosolic ion milieu: the combination of asebotoxin-III and dihydroouabain (which increase intracellular Na+) caused an increase in Ca2+ levels in the final stage (phase III) with a manifestation of contracture after the reperfusion of the heart. "
3.	Hemorrhage 02/01/1983 - "Asebotoxin III (ATX-III), a diterpenoid isolated from the leaves of Asebi, Pieris japonica, was found to produce hemorrhage into the lungs when the toxin in a dose of 2-8 micrograms was injected into the lateral ventricle of guinea pigs under urethane anesthesia (0.8 g/kg, i.p.). "
4.	Contracture 01/01/1998 - "These triphasic changes during ischemia were affected by various agents that affect the cytosolic ion milieu: the combination of asebotoxin-III and dihydroouabain (which increase intracellular Na+) caused an increase in Ca2+ levels in the final stage (phase III) with a manifestation of contracture after the reperfusion of the heart. "

1.	Anesthesia