HOME
PRODUCTS
COMPANY
CONTACT
FAQ
Research
Dictionary
Pharma
Sign Up
FREE
or
Login
Username:
Password:
Remember login
Login
Send password reminder...
orpanoxin
Also Known As:
5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoic acid; F-776
Networked:
4
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Organic Chemicals: 133
Carboxylic Acids: 973
Acyclic Acids
Propionates: 988
orpanoxin: 4
Lipids: 114793
Fatty Acids: 27405
Volatile Fatty Acids: 3052
Propionates: 988
orpanoxin: 4
Related Diseases
1.
Edema (Dropsy)
07/01/1985 - "
It was concluded that orpanoxin has anti-inflammatory activity comparable to reference NSAIDs in the rat paw edema test, is active orally in rat, mouse, and guinea-pig models, and shows topical activity in the guinea-pig and the mouse.
"
02/01/1993 - "
Two chemically similar nonsteroidal anti-inflammatory drugs, orpanoxin and F-1067, had almost identical potencies and efficacies as anti-inflammatory (rat paw edema) and analgesic (mouse writhing) agents, but differed markedly in gastrotoxicity.
"
07/01/1985 - "
Orpanoxin, a nonsteroidal anti-inflammatory drug (NSAID) lacking gastric ulcerogenic effects in the therapeutic dose range in rats, was compared with six reference NSAIDs for oral activity in the rat paw carrageenin-induced edema assay.
"
01/01/1988 - "
F-1044 had antiinflammatory activity equivalent to ibuprofen's and orpanoxin's in the carrageenin-induced paw edema model in normal and adrenalectomized rats.
"
2.
Stomach Ulcer (Gastric Ulcer)
02/01/1980 - "
F-776, 5-(4-chlorophenyl)-beta-hydroxy-2-furanpropanoic acid, is a nonsteroidal anti-inflammatory, analgesic, and antipyretic drug which does not produce stomach ulcers.
"
3.
Erythema
07/01/1985 - "
Oral activity of orpanoxin was also demonstrated in the guinea-pig u.v.-induced erythema model (ED50 = 24.2 mg/kg p.o.
"
07/01/1985 - "
In the guinea-pig u.v.-induced erythema model, application (1 h after u.v.) of 1, 5, and 10% (w/v) orpanoxin creams (containing 10% urea) significantly inhibited erythema at 2, 3, and 4 h post-irradiation.
"
07/01/1985 - "
Orpanoxin, mefenamic acid, and indomethacin as 1% creams inhibited total erythema scores 70, 92 and 74%, respectively.
"
4.
Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)
02/01/1980 - "
F-776 is not an immunosuppressant as determined in the experimental allergic encephalomyelitis rat model.
"
Related Drugs and Biologics
1.
Carrageenan
2.
Analgesics (Analgesic Drugs)
3.
orpanoxin
4.
Antipyretics
5.
Urea (Carbamide)
6.
Mefenamic Acid (Pontal)
7.
Indomethacin (Indometacin)
8.
Immunosuppressive Agents (Immunosuppressants)
9.
Ibuprofen (Motrin)
10.
Non-Steroidal Anti-Inflammatory Agents (NSAIDs)