|1.||Thompson, John A: 2 articles (10/2005 - 12/2004)|
|2.||Meier, Brent W: 2 articles (10/2005 - 12/2004)|
|3.||Gomez, Jose D: 2 articles (10/2005 - 12/2004)|
|4.||Voelkel, Norbert F: 1 article (03/2006)|
|5.||Diaz del Valle, Fernando: 1 article (03/2006)|
|6.||Winn, Robert A: 1 article (03/2006)|
|7.||Douglas, Ivor S: 1 article (03/2006)|
|8.||Zhou, Angela: 1 article (10/2005)|
|9.||Lemercier, Jean-Noël: 1 article (12/2004)|
08/01/1996 - "Indeed, 4-CD3-BHTOOH, an analogue that generates less of the metabolite BHT-quinone methide (2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone) and fewer tumors in vivo, accordingly exhibited diminished potency for activating ERK. "
05/01/1994 - "Taken together, these results provide insight into the cellular mechanisms through which the reactive electrophile BHT-quinone methide can mediate alterations in gene expression, such as occur in tumor promotion in vivo."
09/01/1993 - "BHT-QM has also been demonstrated to mediate tumor promotion in mouse skin by another metabolite of BHT, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadienone (BHTOOH). "
10/01/2005 - "Two quinone methide (QM) metabolites of the phenolic antioxidant butylated hydroxytoluene (BHT), 2,6-di-tert-butyl-4-methylenecyclohexa-2,5-dienone (BHT-QM) and the tert-butyl-hydroxylated derivative (BHTOH-QM), are believed to be responsible for promoting lung tumor formation in mice treated with BHT. "
12/01/2004 - "The present work was undertaken to determine if glutathione S-transferase P1-1 (GSTP1-1) is alkylated by BHT-QM, as this protein is overexpressed in tumors and has important roles in protecting cells from electrophiles and oxidants and in regulating stress kinases. "
|3.||Body Weight (Weight, Body)
03/01/1987 - "Male Sprague-Dawley rats were given butylated hydroxytoluene (BHT) in a dose of 800 mg/kg body weight orally, and 0.5-72 hr later plasma concentrations of factors II, VII, IX and X and hepatic levels of BHT and BHT quinone methide (2,6-di-tert-butyl-4-methylene-2,5-cyclohexadienone) were determined. "
|1.||Butylated Hydroxytoluene (BHT)
|2.||2,6- di- tert- butyl- 4- hydroperoxy- 4- methyl- 2,5- cyclohexadienone
|3.||2,6- di- tert- butyl- 4- methylene- 2,5- cyclohexadienone
|4.||Oxidants (Oxidizing Agents)
|6.||Hydrogen Peroxide (Hydroperoxide)
|7.||Glutathione Transferase (Glutathione S-Transferase)