pyroglutaminyl-seryl-leucinamide

Also Known As:

Pyr-Ser-Leu-NH2; TRH-AN; pyro-Gln-Ser-Leu-amide; pyroglutamine-serine-leucinamide; pyroglutamylserylleucinamide; thyrotropin releasing hormone-AN; L-Leucinamide, 5-oxo-L-prolyl-L-seryl-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - pyroglutaminyl-seryl-leucinamide: 4
- Amino Acids: 30675
  - Acidic Amino Acids: 44
    - Glutamates: 45
      - Pyrrolidonecarboxylic Acid: 255
        pyroglutaminyl-seryl-leucinamide: 4
  - Cyclic Amino Acids: 3
    - Imino Acids: 11
      - Pyrrolidonecarboxylic Acid: 255
        pyroglutaminyl-seryl-leucinamide: 4
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrrolidines: 115
    - Pyrrolidinones: 162
      - Pyrrolidonecarboxylic Acid: 255
        pyroglutaminyl-seryl-leucinamide: 4

Related Diseases

1.	Nervous System Diseases (Neurological Disorders) 07/01/1990 - "Thyrotropin releasing hormone (TRH), an endogenous tripeptide of the spinal cord, is being used in clinical trials for the treatment of neurological disorders involving the spinal function. "
2.	Thyroid Neoplasms (Thyroid Cancer) 04/30/1990 - "Incubation of rat thyroid carcinoma CA77 cells in the presence of 4-phenyl-3-butenoic acid led to a decrease in the levels of intracellular amidating activity and of thyrotropin-releasing hormone, an amidated peptide produced by these cells. "
3.	Hyperthyroidism 10/12/1979 - "The patients with a hyperthyroidism had neither after the intravenous nor after the oral application of TRH an increase of the peripheral concentration of TSH. "
4.	Body Weight (Weight, Body) 03/01/1989 - "A few minutes (1.89 +/- 1.30 min) after the administration of TRH, the secretion of TSH (0.025 +/- 0.016 microU/min ml) was stimulated, and the total release over about 1 h was 12.5 +/- 5.6 microU/ml. Serum TSH was maximum at 31.5 +/- 5.7 min. The half-time of disappearance of TSH was 42 +/- 9 min. These data confirm that the stimulated secretion continues for more than 30 min, and that the pituitary releases 43.2 +/- 22.9 mU of TSH (assuming the distribution volume of TSH is 5.8% of body weight) in response to TRH, an amount which correlates closely (r = 0.91) with TSH before TRH administration."

Related Drugs and Biologics

1.	Thyrotropin-Releasing Hormone (Protirelin)
2.	Peptides (Polypeptides)
3.	4-phenyl-3-butenoic acid