fosmidomycin

from Streptomyces lavendulae; RN given refers to parent cpd; structure in second source

Also Known As:

3-(N-formyl-N-hydroxy)aminopropylphosphonic acid; FR-31564; fosfidomycin; fosmidomycin monoammonium salt; fosmidomycin monopotassium salt; fosmidomycin monosodium salt; fosmidomycin sodium; fosmidomycin sodium salt; phosphonic acid, (3-(formylhydroxyamino)propyl)-, monosodium salt; (3-(formylhydroxyamino)propyl)phosphonic acid, monosodium salt

Networked: 56 relevant articles (11 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - Fosfomycin: 1200
      - fosmidomycin: 56

Experts

1.	Jomaa, Hassan: 13 articles (05/2011 - 09/2002)
2.	Wiesner, Jochen: 12 articles (05/2011 - 09/2002)
3.	Kremsner, Peter G: 9 articles (01/2018 - 12/2002)
4.	Hutchinson, David: 8 articles (01/2018 - 02/2003)
5.	Issifou, Saadou: 6 articles (05/2007 - 12/2002)
6.	Borrmann, Steffen: 6 articles (08/2006 - 12/2002)
7.	Na-Bangchang, Kesara: 5 articles (09/2010 - 04/2007)
8.	Adegnika, Ayola A: 5 articles (08/2006 - 12/2002)
9.	Matsiegui, Pierre-Blaise: 5 articles (08/2006 - 12/2002)
10.	Lell, Bertrand: 4 articles (01/2018 - 12/2002)

Related Diseases

1.	Malaria 12/14/2002 - "These data suggest that fosmidomycin is a safe and effective treatment for uncomplicated malaria if given for 4 days or more." 09/01/2005 - "Fosmidomycin is effective against malaria, but it needs to be given for > or =4 days when used alone. " 08/01/2003 - "This compound, fosmidomycin, has been shown to be somewhat effective in treating Plasmodium falciparum, the parasite responsible for malaria. " 05/19/2005 - "This target has been characterized as having potential in the treatment of malaria with fosmidomycin, an established DXR inhibitor, presently in clinical trials. " 12/21/2018 - "We identified several previously unreported mutations that confer fosmidomycin resistance, in highly conserved sites that also exist in pathogens including the malaria-inducing Plasmodium falciparum. "
2.	Falciparum Malaria (Plasmodium falciparum Malaria) 06/01/2003 - "In recent clinical studies it was shown that fosmidomycin is effective in curing uncomplicated Plasmodium falciparum malaria in humans. " 12/01/2017 - "Fosmidomycin is a promising DXR inhibitor, which showed safety as well as efficacy against Plasmodium falciparum malaria in clinical trials. " 05/01/2010 - "The method appears to be robust and has been applied to a pharmacokinetic study to determine the plasma and urinary excretion of fosmidomycin in a total of 24 Thai patients with acute uncomplicated falciparum malaria following oral doses of 1800 fosmidomycin given every 10 h for 3 days." 02/01/2003 - "In this open-label, uncontrolled trial, the efficacy and safety of fosmidomycin, in an oral dose of 1,200 mg every 8 h for 7 days, were evaluated in the treatment of acute uncomplicated Plasmodium falciparum malaria in 20 adult subjects in Gabon and Thailand. " 09/01/2002 - "In a recent clinical study, fosmidomycin was effective and well tolerated in the treatment of patients with acute uncomplicated Plasmodium falciparum malaria but resulted in an unacceptably high rate of recrudescence. "
3.	Infections 01/01/2003 - "[Effect of fosfidomycin on development of various infections in mice]." 02/01/2003 - "Fosmidomycin is an effective and safe antimalarial drug, although its use as a single agent is restricted by the occurrence of recrudescent infections. " 09/01/2016 - "We have identified fosmidomycin as an antibiotic that selectively targets certain Staphylococcus species that are often encountered in skin infections in cats and dogs. " 03/01/2004 - "Fosmidomycin-clindamycin for Plasmodium falciparum Infections in African children." 03/01/2004 - "We conducted a randomized, controlled, open-label study to evaluate the efficacy and safety of fosmidomycin combined with clindamycin (n=12; 30 and 5 mg/kg body weight every 12 h for 5 days, respectively), compared with fosmidomycin alone (n=12; 30 mg/kg body weight every 12 h for 5 days) and clindamycin alone (n=12; 5 mg/kg body weight every 12 h for 5 days) for the clearance of asymptomatic Plasmodium falciparum infections in schoolchildren in Gabon aged 7-14 years. "
4.	Body Weight (Weight, Body) 01/01/1982 - "After i.v. administration of 10 mg/kg of body weight, [14C]-fosmidomycin was excreted mainly in the urine (about 90% of dose within 72 h); and only a little was excreted in the expired air (14CO2) and bile of rats (less than 1% of dose), which suggested the absence of enterohepatic circulation. " 08/01/2006 - "We conducted a single-arm study to improve the precision of efficacy estimates for an oral 3-day fixed-ratio combination of fosmidomycin and clindamycin at 30 and 10 mg/kg of body weight, respectively, every 12 hours for the treatment of uncomplicated P. " 09/01/2005 - "We conducted a study of 50 children with Plasmodium falciparum malaria to evaluate the safety and efficacy of consecutively shortened regimens of artesunate-fosmidomycin (1 to 2 mg/kg of body weight and 30 mg/kg of body weight, respectively; doses given every 12 hours). " 03/01/2004 - "We conducted a randomized, controlled, open-label study to evaluate the efficacy and safety of fosmidomycin combined with clindamycin (n=12; 30 and 5 mg/kg body weight every 12 h for 5 days, respectively), compared with fosmidomycin alone (n=12; 30 mg/kg body weight every 12 h for 5 days) and clindamycin alone (n=12; 5 mg/kg body weight every 12 h for 5 days) for the clearance of asymptomatic Plasmodium falciparum infections in schoolchildren in Gabon aged 7-14 years. " 11/01/2004 - "falciparum malaria in Gabon to evaluate the efficacy and safety of an oral combination of fosmidomycin-clindamycin of 30 mg/kg and 10 mg/kg of body weight, respectively, every 12 h. "
5.	Staphylococcal Infections 09/01/2016 - "These data identify an essential metabolic pathway in Staphylococcus that differs among members of this genus and suggest that drugs such as fosmidomycin, which targets enzymes in the nonmevalonate pathway, may be an effective treatment for certain staphylococcal infections. "

Related Drugs and Biologics

1.	Clindamycin (Cleocin)
2.	Enzymes
3.	Artesunate
4.	Antimalarials (Antimalarial Agents)
5.	Gentamicins (Gentamicin)
6.	Fosfomycin
7.	artemisinin (artemisinine)
8.	Anti-Infective Agents (Microbicides)
9.	Acids
10.	Terpenes (Terpenoids)

Related Therapies and Procedures

1.	Therapeutics