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Geraniin

in various plants; structure in first source
Also Known As:
beta-D-glucopyranose, cyclic 3,6-(4,4',5,5',6,6'-hexahydroxy(1,1'-biphenyl)-2,2'-dicarboxylate) 1-(3,4,5-trihydroxybenzoate), cyclic 2-2:4-1-ester with 2-(2-carboxy-4,5,6-trioxo-2-cyclohexen-1-yl)-3,4,5-trihydroxybenzoic acid
Networked: 13 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. He, Bo: 2 articles (02/2015 - 02/2013)
2. Chen, Peng: 2 articles (02/2015 - 02/2013)
3. Ko, Hyeonseok: 1 article (09/2015)
4. Yun, Yu: 1 article (02/2015)
5. Shen, Zhiqiang: 1 article (02/2015)
6. Song, Bo: 1 article (02/2015)
7. Zhang, Yue: 1 article (02/2015)
8. Yan, Hongli: 1 article (02/2015)
9. Zhang, Xiaochao: 1 article (02/2015)
10. Li, Shude: 1 article (02/2015)

Related Diseases

1. Osteolysis
2. Rhabdomyosarcoma
3. Osteoporosis
4. Neoplasms (Cancer)
5. Melanoma (Melanoma, Malignant)
06/01/2008 - "Here, we investigated the mechanism of geraniin-induced apoptosis in human melanoma cells and demonstrated that geraniin was able to induce cell apoptosis in a concentration- and time-dependent manner. "
06/01/2008 - "To clarify the relationship between focal adhesion kinase (FAK) and geraniin-induced apoptosis, we treated human melanoma cells with geraniin and found that this resulted dose- and time-dependent degradation in FAK. "
06/01/2008 - "Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells."
08/01/1992 - "Among them, chebulagic acid [1], geraniin [2], sanguiin H-11 [3], 4,5-di-O-galloylquinic acid [12], 1,3,4,5-tetra-O-galloylquinic acid [15], 1(beta)-O-galloylpedunculagin [24], furosin [29], castalagin [38], sanguiin H-2 [34], vescalagin [39], grandinin [40], phyllyraeoidin A [42], (-)-epicatechin 3-O-gallate [50], cinnamtannin B2 [55], and acutissimin A [56] exhibited moderate selective cytotoxicity against PRMI-7951 melanoma cells with ED50 values in the range of 0.1-0.8 microgram/ml. Selective cytotoxicities against the melanoma cells were also observed for strictinin [22], pedunculagin [23], eugeniin [25], elaeocarpusin [28], punicacortein C [37], casuarinin [41], sanguiin H-6 [43], procyanidin B-2 3,3'-di-O-gallate [51], procyanidin C-1 3,3',3"-tri-O-gallate [52], and cinnamtannin B1 [54] with ED50 values of 1-4 micrograms/ml. All of the tannins were found to be inactive (greater than 10 micrograms/ml) against lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of nasopharnyx (KB), and medulloblastoma (TE-671) tumor cells."

Related Drugs and Biologics

1. Tretinoin (Retinoic Acid)
2. Okadaic Acid
3. Tannins (Tannic Acid)
4. Fas Ligand Protein (Fas Ligand)
5. Focal Adhesion Protein-Tyrosine Kinases
6. Matrix Metalloproteinase 9 (Gelatinase B)
7. Lamivudine (3TC)
8. Hepatitis B Surface Antigens (HBsAg)
9. Hepatitis B e Antigens
10. Catechin (Z 7300)

Related Therapies and Procedures

1. Prostheses and Implants (Prosthesis)
2. Heterologous Transplantation (Xenotransplantation)