|1.||He, Bo: 2 articles (02/2015 - 02/2013)|
|2.||Chen, Peng: 2 articles (02/2015 - 02/2013)|
|3.||Ko, Hyeonseok: 1 article (09/2015)|
|4.||Yun, Yu: 1 article (02/2015)|
|5.||Shen, Zhiqiang: 1 article (02/2015)|
|6.||Song, Bo: 1 article (02/2015)|
|7.||Zhang, Yue: 1 article (02/2015)|
|8.||Yan, Hongli: 1 article (02/2015)|
|9.||Zhang, Xiaochao: 1 article (02/2015)|
|10.||Li, Shude: 1 article (02/2015)|
01/01/2015 - "Geraniin suppresses RANKL-induced osteoclastogenesis in vitro and ameliorates wear particle-induced osteolysis in mouse model."
01/01/2015 - "In this study, we demonstrated for the first time that geraniin, an active natural compound derived from Geranium thunbergii, ameliorated particle-induced osteolysis in a Ti particle-induced mouse calvaria model in vivo. "
01/01/2015 - "Collectively, our data suggested that geraniin exerts inhibitory effects on osteoclast differentiation in vitro and suppresses Ti particle-induced osteolysis in vivo. "
01/01/2015 - "Geraniin is therefore a potential natural compound for the treatment of wear particle induced osteolysis in prostheses failure. "
03/15/2012 - "The results showed that geraniin effectively inhibited virus replication in rhabdomyosarcoma cells with an IC(50) of 10 μg/ml. Moreover, geraniin treatment of mice that were challenged with a lethal dose of enterovirus 71 resulted in a reduction of mortality, relieved clinical symptoms, and inhibited virus replication in muscle tissues. "
02/01/2015 - "In the present study, we investigated the antiosteoporotic effect of geraniin on osteoporosis induced by OVX in rats. "
02/01/2015 - "These results indicated that geraniin have a protective effect against OVX-induced rat osteoporosis. "
02/01/2013 - "In our previous studies, geraniin was reported to have a preventive effect in the rat model of tretinoin-induced osteoporosis. "
12/01/2013 - "In this study, we reported that geraniin is an inhibitor of tumor activity in vitro and in vivo. "
12/01/2013 - "Our results indicate cytotoxic activity of geraniin towards cancer cells in vitro and in vivo. "
06/01/2008 - "The geraniin-induced apoptosis may provide a pivotal mechanism for its cancer-chemopreventive action."
02/01/2003 - "Considering seasonal variations of the agents and sites of cultivation of herbs, this paper reviews the significance of geraniin as a new cancer preventive agent. "
12/01/2013 - "Additionally, geraniin resulted in tumor growth inhibition in A549 xenografts. "
|5.||Melanoma (Melanoma, Malignant)
06/01/2008 - "Here, we investigated the mechanism of geraniin-induced apoptosis in human melanoma cells and demonstrated that geraniin was able to induce cell apoptosis in a concentration- and time-dependent manner. "
06/01/2008 - "To clarify the relationship between focal adhesion kinase (FAK) and geraniin-induced apoptosis, we treated human melanoma cells with geraniin and found that this resulted dose- and time-dependent degradation in FAK. "
06/01/2008 - "Geraniin-mediated apoptosis by cleavage of focal adhesion kinase through up-regulation of Fas ligand expression in human melanoma cells."
08/01/1992 - "Among them, chebulagic acid , geraniin , sanguiin H-11 , 4,5-di-O-galloylquinic acid , 1,3,4,5-tetra-O-galloylquinic acid , 1(beta)-O-galloylpedunculagin , furosin , castalagin , sanguiin H-2 , vescalagin , grandinin , phyllyraeoidin A , (-)-epicatechin 3-O-gallate , cinnamtannin B2 , and acutissimin A  exhibited moderate selective cytotoxicity against PRMI-7951 melanoma cells with ED50 values in the range of 0.1-0.8 microgram/ml. Selective cytotoxicities against the melanoma cells were also observed for strictinin , pedunculagin , eugeniin , elaeocarpusin , punicacortein C , casuarinin , sanguiin H-6 , procyanidin B-2 3,3'-di-O-gallate , procyanidin C-1 3,3',3"-tri-O-gallate , and cinnamtannin B1  with ED50 values of 1-4 micrograms/ml. All of the tannins were found to be inactive (greater than 10 micrograms/ml) against lung carcinoma (A-549), ileocecal adenocarcinoma (HCT-8), epidermoid carcinoma of nasopharnyx (KB), and medulloblastoma (TE-671) tumor cells."
|1.||Tretinoin (Retinoic Acid)
|3.||Tannins (Tannic Acid)
|4.||Fas Ligand Protein (Fas Ligand)
|5.||Focal Adhesion Protein-Tyrosine Kinases
|6.||Matrix Metalloproteinase 9 (Gelatinase B)
|8.||Hepatitis B Surface Antigens (HBsAg)
|9.||Hepatitis B e Antigens
|10.||Catechin (Z 7300)
|1.||Prostheses and Implants (Prosthesis)
|2.||Heterologous Transplantation (Xenotransplantation)