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1,1,2-trichloroethane

RN given refers to cpd with locants as specified

Also Known As:

1,1,2-trichloroethane, 14C-2-labeled; 1,1,2-trichloroethane, 36Cl-labeled; ethane, 1,1,2-trichloro-

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Chlorinated Hydrocarbons: 240
      - Trichloroethanes
        1,1,2-trichloroethane: 5

Experts

1.	Teschke, Rolf: 1 article (12/2018)
2.	Brender, Jean D: 1 article (11/2014)
3.	Gong, Xi: 1 article (11/2014)
4.	Langlois, Peter H: 1 article (11/2014)
5.	Shinde, Mayura U: 1 article (11/2014)
6.	Zhan, F Benjamin: 1 article (11/2014)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 01/01/1978 - "In both male and female mice, administration of 1,1,2-trichloroethane was associated with a significantly increased incidence of hepatocellular carcinomas. " 01/01/1978 - "Under the conditions of this bioassay 1,1,2-trichloroethane is carcinogenic in B6C3F1 mice, causing hepatocellular carcinomas and adrenal pheochromocytomas." 01/01/1978 - "Both the Fisher exact test comparing tumor incidences of dosed to control groups and the Cochran-Armitage test for positive dose-related trend indicated a highly significant (P<0.001) association between hepatocellular carcinomas in all mouse groups and the administration of 1,1,2-trichloroethane. " 12/01/1977 - "Most of the compounds, namely, trichloroethylene, 1,1-dichloroethane, 1,1,2-trichloroethane, hexachloroethane, and tetrachloroethylene, increased hepatocellular carcinomas in mice but had little or no action in rats. "
2.	Pheochromocytoma 01/01/1978 - "A positive dose-related association between administration of 1,1,2-trichloroethane and the incidence of pheochromocytoma of the adrenal gland was indicated by the Cochran-Armitage test for mice of both sexes. " 01/01/1978 - "Under the conditions of this bioassay 1,1,2-trichloroethane is carcinogenic in B6C3F1 mice, causing hepatocellular carcinomas and adrenal pheochromocytomas."
3.	Neural Tube Defects (Exencephaly) 11/19/2014 - "Relative to exposure risk values of 0, neural tube defects were associated with maternal residential exposures (exposure risk values >0) to several types of chlorinated solvents, most notably carbon tetrachloride (adjusted odds ratio [aOR] 1.42, 95% confidence interval [CI] 1.09, 1.86); chloroform (aOR 1.40, 95% CI 1.04, 1.87); ethyl chloride (aOR 1.39, 95% CI 1.08, 1.79); 1,1,2-trichloroethane (aOR 1.56, 95% CI 1.11, 2.18); and 1,2,3-trichloropropane (aOR 1.49, 95% CI 1.08, 2.06). "
4.	Neoplasms (Cancer) 01/01/1978 - "Both the Fisher exact test comparing tumor incidences of dosed to control groups and the Cochran-Armitage test for positive dose-related trend indicated a highly significant (P<0.001) association between hepatocellular carcinomas in all mouse groups and the administration of 1,1,2-trichloroethane. "
5.	Hyperventilation 12/28/2018 - "Methods: Analyzed were data of 60 patients intoxicated by AHH, such as dichloromethane (n = 3), chloroform (n = 2), carbon tetrachloride (n = 12), 1,2-dichloroethane (n = 18), 1,1,2-trichloroethane (n = 2), trichloroethylene (n = 2), tetrachloroethylene (n = 13) or mixed AHH chemicals (n = 8), who received a new treatment consisting of CO2-induced hyperventilation to accelerate toxin removal via the lungs. "

Related Drugs and Biologics

1.	Trichloroethylene (Trichloroethene)
2.	Tetrachloroethylene (Tetrachloroethene)
3.	Solvents
4.	Chloroform (Trichloromethane)
5.	Carbon Tetrachloride (Tetrachloromethane)
6.	Toluene
7.	Methylene Chloride (Dichloromethane)
8.	Ethyl Chloride (Chloroethane)
9.	1,1-dichloroethane
10.	ethylene dichloride (1,2-dichloroethane)