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ethylene dichloride (1,2-dichloroethane)

RN given refers to 1,2-isomer; structure given in first source
Also Known As:
1,2-dichloroethane; ethylene dichloride, 14C-labeled; ethylene dichloride, 14C2-labeled; ethylene dichloride, 36Cl-labeled; ethylene dichloride, 38Cl-labeled; ethylene dichloride, ion (1+); ethane, 1,2-dichloro-
Networked: 80 relevant articles (1 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Jin, Yaping: 12 articles (11/2021 - 07/2014)
2. Wang, Gaoyang: 12 articles (11/2021 - 07/2014)
3. Zhao, Fenghong: 11 articles (11/2021 - 01/2016)
4. Wang, Tong: 8 articles (11/2021 - 01/2016)
5. Liao, Yingjun: 8 articles (12/2019 - 01/2016)
6. Sun, Qi: 6 articles (11/2021 - 01/2016)
7. Jin, Xiaoxia: 5 articles (10/2021 - 01/2018)
8. Huang, Zhenlie: 4 articles (02/2022 - 01/2017)
9. Rong, Weifeng: 4 articles (02/2022 - 01/2017)
10. Tan, Xiaoqiong: 4 articles (12/2018 - 07/2014)

Related Diseases

1. Poisoning
2. Brain Edema (Cerebral Edema)
3. Neoplasms (Cancer)
4. Adenocarcinoma
01/01/2016 - "An inhalation unit risk factor (URF) was developed for ethylene dichloride (EDC, CAS 107-06-2) based on tumorigenicity results observed in a 2-year animal inhalation study conducted by Nagano et al. More specifically, the incidence of combined mammary gland tumors (adenomas, fibroadenomas, adenocarcinomas) in female rats demonstrated a statistically significant dose-response relationship, was amenable to benchmark concentration (BMC) modeling, was ultimately determined to be the most sensitive tumorigenic effect in the most sensitive species and sex, and was utilized as the carcinogenic endpoint for the development of the URF. "
01/01/1978 - "Under the conditions of this study, 1,2-dichloroethane was carcinogenic to Osborne-Mendel rats, causing squamous-cell carcinomas of the forestomach, hemangiosarcomas, and subcutaneous fibromas in male rats and causing mammary adenocarcinomas in female rats. "
01/01/2017 - "To investigate the suitability of using the rasH2 mouse to test carcinogenic potential, 1,2-dichloroethane (1,2-DCE) was dermally applied to rasH2 mice: 1,2-DCE is a known carcinogen that causes lung bronchiolo-alveolar adenomas and adenocarcinomas when administered topically, orally, or by inhalation exposure; 1,2-DCE at a dose level of 126 mg/mouse in 200 μl acetone or acetone alone (vehicle control) was applied to the dorsal skin of 10 mice of each sex 3 times a week for 26 weeks. "
11/01/2006 - "Carcinogenicity and chronic toxicity of 1,2-dichloroethane (DCE) were examined by inhalation exposure of groups of 50 F344 rats and 50 BDF1 mice of both sexes to DCE vapor or clean air as control for 6 h/d, 5 d/wk and 104 wk. The rats were exposed to 10, 40 or 160 ppm (v/v) DCE, while the mice were exposed to 10, 30 or 90 ppm. The 2-yr exposure to DCE produced a dose-dependent increase in incidences of benign and malignant tumors, including subcutaneous fibroma, mammary gland fibroadenoma and peritoneal mesothelioma in male rats; subcutaneous fibroma and mammary gland adenoma, fibroadenoma and adenocarcinoma in female rats; and bronchiolo-alveolar adenoma and carcinoma, endometrial stromal polyp, mammary gland adenocarcinoma and hepatocellular adenoma in female mice. "
5. Neurotoxicity Syndromes (Toxic Encephalopathy)

Related Drugs and Biologics

1. Organophosphorus Compounds
2. Charcoal (Charbon)
3. Benzene (Benzole)
4. Chloroform (Trichloromethane)
5. Acrolein (Aqualin)
6. 1,3-butadiene (divinyl)
7. Tight Junction Proteins
8. Matrix Metalloproteinases (MMPs)
9. Matrix Metalloproteinase 2 (Gelatinase A)
10. Aquaporins (Water Channels)

Related Therapies and Procedures

1. Hemoperfusion
2. Occupational Therapy (Therapy, Occupational)
3. Intraperitoneal Injections
4. Oral Administration
5. Contraindications