bicozamycin (FR 1881)

02/01/1985 - "Efficacy of bicozamycin in preventing traveler's diarrhea."
05/01/1986 - "None of 11 students given bicozamycin (500 mg four times daily) developed diarrhea during a three-week study, whereas 10 (53%) of 19 placebo recipients became ill (P = .003). "
04/01/1983 - "During a therapeutic trial of bicozamycin (BI) for traveler's diarrhea, aerobically grown, gram-negative bacteria, predominantly Escherichia coli, were decreased by 2 to 3 logs per g of stool; the number of BI-resistant gram-negative bacteria did not increase. "
04/01/1983 - "Bacteriological studies of the enteric flora of patients treated with bicozamycin (CGP 3543/E) for acute nonparasitic diarrhea."
02/01/1985 - "Bicozamycin seems to be well suited and safe as a prophylactic agent against traveler's diarrhea."

01/01/2023 - "These data demonstrate that bicyclomycin-containing regimens have potential as new treatment options for MDR Gram-negative infections such as those caused by CRE, E. "
01/01/2023 - "Thus, bicyclomycin, which has largely been limited to the treatment of Gram-negative digestive tract infections, can now be considered for the combination treatment of systemic multidrug-resistant infections caused by CRE, E. "
01/01/2023 - "In a murine model of infection, the bicyclomycin-doxycycline combination showed better efficacy than either agent alone, and the combination treatment largely eliminated histopathological manifestations caused by infection. "
01/01/2001 - "Bicozamycin (BCM) which inhibits protein synthesis by inhibiting Rho-dependent transcription termination factor ATPase activity is used for treatment of animal infections. "

01/01/1983 - "Cramps were significantly relieved by bicozamycin in all patients. "

12/01/1974 - "Therapeutic efficacy of bicyclomycin for shigellosis experimentally induced in rhesus monkeys."

01/01/2022 - "tuberculosis Rho [MtbRho] factor displays poor NTPase and helicase activities, and resistance to the natural Rho inhibitor bicyclomycin [BCM] that remain unexplained. "