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RN given refers to (L)-isomer
Also Known As:
tetrahydromethotrexate, (DL)-isomer; L-glutamic acid, N-(4-(((2,4-diamino-5,6,7,8-tetrahydro-6-pteridinyl)methyl)methylamino)benzoyl)-
relevant articles (
Bio-Agent Context: Research Results
Heterocyclic Compounds: 60
2-Ring Heterocyclic Compounds
07/01/1977 - "
Although dihydroaminopterin and tetrahydromethotrexate increased the survival rate of mice bearing L1210 tumors, these compounds had no such effect on the life-spans of animals with L1210/MTX tumors.
Body Weight (Weight, Body)
01/01/1977 - "
Uptake and conversion of [3H]folic acid to polyglutamate derivatives by rat liver and kidney were inhibited by methotrexate or aminopterin (15 mg/kg body weight) and DL-tetrahydromethotrexate (30 mg/kg body weight).
Related Drugs and Biologics
Polyglutamic Acid (Polyglutamate)
Folic Acid (Vitamin M)
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