phenacylamine

RN given refers to parent cpd; structure in Merck Index, 9th ed, #6990

Also Known As:

alpha-aminoacetophenone; phenacylamine hydrobromide; phenacylamine monohydrochloride; 2-amino-1-phenylethanone

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 06/01/1983 - "Bestatin, an immunomodulator useful in cancer treatment with the structure: N-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl]-L-leucine, has been synthesized from N-acyl-alpha-aminoacetophenone. "
2.	Dehydration (Water Stress) 06/25/1984 - "Mechanistically significant findings presented herein include: 1) an analysis of primary deuterium isotope effects on turnover, indicating major differences in rate-determining steps for beta-chloro- and beta- hydroxyphenethylamine hydroxylation, Dkcat = 6.1 and 1.0, respectively; 2) evidence that dehydration of the gem-diol derived from oxygen- 18-labeled beta- hydroxyphenethylamine hydroxylation occurs in a random manner, attributed to dissociation of enzyme-bound gem-diol prior to alpha-aminoacetophenone formation; 3) the observation of a deuterium isotope effect for beta- chlorophenethylamine inactivation, Dkinact = 3.7, implicating C--H bond cleavage in the inactivation process; and 4) the demonstration that alpha-aminoacetophenone can replace ascorbic acid as exogenous reductant in the hydroxylation of tyramine. "

1.	Reducing Agents
2.	2-Hydroxyphenethylamine
3.	Tyramine
4.	Oxygen (Dioxygen)
5.	Leucine (L-Leucine)
6.	Isotopes
7.	Immunologic Factors (Immunomodulators)
8.	Enzymes
9.	Deuterium
10.	Ascorbic Acid (Vitamin C)