|1.||Oki, Takashi: 1 article (09/2004)|
|2.||Oishi, Yoshifumi: 1 article (09/2004)|
|3.||Mizuguchi, Yukio: 1 article (09/2004)|
|4.||Ishimoto, Takeo: 1 article (09/2004)|
|5.||Nagase, Norio: 1 article (09/2004)|
|6.||Emi, Shigefumi: 1 article (09/2004)|
|7.||Kageyama, Norihito: 1 article (09/2004)|
|8.||Suzuki, Yoshiyuki: 1 article (11/2003)|
|9.||Miyamoto, Noriyuki: 1 article (11/2003)|
|10.||Kojima, Masakazu: 1 article (11/2003)|
06/01/1987 - "We assessed the electrophysiologic effects and antiarrhythmic efficacy of intravenous pirmenol in 15 patients who had spontaneous and induced sustained ventricular tachyarrhythmias. "
06/01/1987 - "Electrophysiology and antiarrhythmic efficacy of intravenous pirmenol in patients with sustained ventricular tachyarrhythmias."
06/15/1987 - "Pirmenol was effective in 3 of 5 patients with atrioventricular nodal reentrant mechanism, but in none of 3 patients with a reentrant tachycardia with a retrogradely conducting atrioventricular bypass tract. "
12/01/1998 - "Pirmenol hydrochloride is a new orally effective, long-acting antiarrhythmic agent currently used in patients with supraventricular and ventricular tachyarrhythmias. "
04/01/1996 - "A single oral dose of pirmenol was well tolerated as episodic treatment in patients with supraventricular tachyarrhythmias."
|2.||Ventricular Premature Complexes (Premature Ventricular Contraction)
02/01/1984 - "Thus, oral pirmenol appears to be effective, conveniently administered and well tolerated as an antiarrhythmic agent for control of ventricular extrasystoles."
06/15/1987 - "The efficacy of pirmenol in suppressing ventricular premature complexes (VPCs) was assessed in 196 patients in a placebo-controlled, double-blind, multicenter study. "
06/01/1997 - "Pharmacokinetics of pirmenol enantiomers and pharmacodynamics of pirmenol racemate in patients with premature ventricular contractions."
06/15/1987 - "The percentage of responders (premature ventricular contraction suppression of 70% compared with baseline) among the patients receiving 300 mg or 400 mg of pirmenol/day was significantly higher than in the placebo group. "
06/15/1987 - "Metabolic disposition and pharmacokinetics of pirmenol were studied in laboratory animals and in patients with premature ventricular beats. "
03/01/1988 - "The author outlines the effects of pirmenol on the sinus node, atrial tissue, A-V node, and ventricular tissue and describes its antiarrhythmic efficacy in clinical studies to date, including his own study in 21 patients with a history of sustained ventricular tachycardia. "
06/15/1987 - "Twenty patients with ventricular tachycardia refractory to drug treatment underwent electrophysiologic study with pirmenol. "
03/01/1988 - "Of these 13 patients, an additional two patients had their ventricular tachycardias rendered noninducible on pirmenol. "
03/01/1988 - "In patients whose ventricular tachycardias remained inducible on pirmenol, the cycle length was significantly prolonged compared to baseline. "
07/01/1987 - "Ten of 12 patients were still inducible to ventricular tachycardia on pirmenol. "
|4.||Cardiac Arrhythmias (Arrythmia)
04/01/1997 - "Both pirmenol enantiomers were equally effective in arrhythmia suppression. "
01/01/1986 - "Ten patients who had their arrhythmia effectively suppressed by pirmenol in a dose-ranging study were treated with the lowest effective doses in an open investigation. "
03/01/1999 - "Population pharmacokinetic analysis of pirmenol in healthy volunteers and patients with arrhythmia."
03/01/1988 - "Pirmenol was highly effective by both the intravenous and oral routes, causing immediate suppression, prevention, or termination of cardiac arrhythmias. "
06/15/1987 - "Pirmenol was highly effective by both the intravenous and oral routes, causing immediate suppression, prevention or termination of cardiac arrhythmias. "
02/01/1986 - "The efficacy of pirmenol (a class I antiarrhythmic agent) as a converter of paroxysmal atrial fibrillation was investigated. "
01/01/2000 - "Previously she had received pirmenol, at a serum concentration within therapeutic range, for her paroxysmal atrial fibrillation. "
12/01/1998 - "We report on a 56-year-old female who exhibited drug refractory paroxysmal atrial fibrillation, in which marked prolongation of the QT interval and T wave inversion on electrocardiogram was demonstrated reproducibly shortly after the administration of oral pirmenol therapy. "
12/01/1998 - "Pirmenol hydrochloride-induced QT prolongation and T wave inversion on electrocardiogram during treatment for symptomatic atrial fibrillation."
04/01/1996 - "In a different series of patients, we administered a single 200-mg oral dose of pirmenol to evaluate its acute termination effect in 7 patients with PSVT and 9 with paroxysmal atrial fibrillation. "
|4.||Sotalol (Sotalol Hydrochloride)
|8.||Muscarinic Receptors (Muscarinic Acetylcholine Receptor)
|9.||Polyvinyl Chloride (PVC)
|5.||Drug Therapy (Chemotherapy)