pokeweed antiviral protein

Ribosome inactivating protein from PHYTOLACCA; PAP I from spring leaves, PAP II from summer leaves, PAP-R from root, PAP-S & S1 & S2 from seed;

Also Known As:

PAP II protein, Phytolacca americana; PAP III protein, Phytolacca americana; PAP protein, Phytolacca; PAP protein, Phytolacca americana; PAP protein, Phytolacca dodecandra; PAP protein, Phytolacca insularis; PAP-S protein, Phytolacca americana; PAP1 protein, Phytolacca americana; PAP2 protein, Phytolacca americana; PIP protein, Phytolacca insularis; PW-AVP a protein, Phytolacca americana; PW-AVP b protein, Phytolacca americana; Pokeweed antiviral protein, Phytolacca americana leaves; Pokeweed antiviral protein, Phytolacca americana seeds; anti-viral protein, Phytolacca americana; anti-viral protein, pokeweed; antiviral protein, Phytolacca insularis; dodecandrin protein, Phytolacca dodecandra; pokeweed antiviral protein II; pokewood antiviral protein, Phytolacca americana; ribosome inactivating protein, Phytolacca; ribosome-inactivating protein PAP, Phytolacca americana

Networked: 32 relevant articles (2 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Hudak, Katalin A: 2 articles (10/2015 - 01/2008)
2.	Ge, Hui: 1 article (01/2020)
3.	Hassan, Yasser: 1 article (01/2020)
4.	Ogg, Sherry: 1 article (01/2020)
5.	Li, Wenting: 1 article (05/2018)
6.	Li, Yi: 1 article (05/2018)
7.	Wang, Zheng: 1 article (05/2018)
8.	Yin, Ming: 1 article (05/2018)
9.	Yu, Xiaolan: 1 article (05/2018)
10.	Zhang, Yonghong: 1 article (05/2018)

Related Diseases

1.	Virus Diseases (Viral Diseases) 04/15/1997 - "C-terminal deletion mutant of pokeweed antiviral protein inhibits viral infection but does not depurinate host ribosomes." 08/01/1993 - "Exogenous application of pokeweed antiviral protein (PAP), a ribosome-inhibiting protein found in the cell walls of Phytolacca americana (pokeweed), protects heterologous plants from viral infection. " 01/01/1992 - "Pokeweed antiviral protein is among the RIPs that have been conjugated to selective monoclonal antibodies for the treatment of several human cancers and viral diseases. " 03/01/1983 - "Addition of pokeweed antiviral protein to Vero cell monolayers before virus infection was 10 to 15% more effective in reducing virus yields than was the simultaneous addition of the antiviral protein with virus inoculum. "
2.	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma (Leukemia, Pre B Cell) 05/01/1992 - "We used this SCID mouse model of aggressive human pre-B ALL to evaluate the in vivo antileukemic efficacy of B43 (anti-CD19)-pokeweed antiviral protein (PAP) immunotoxin. "
3.	Leukemia 06/01/1990 - "In this report an immunotoxin has been prepared by conjugating pokeweed antiviral protein (PAP) to the 3A1 murine monoclonal antibody that recognizes a 40 kD (CD7) determinant expressed by most T cell acute lymphoblastic leukemias and a majority of normal mature peripheral T cells. " 01/01/1985 - "Increased efficiency in selective elimination of leukemia cells by a combination of a stable derivative of cyclophosphamide and a human B-cell-specific immunotoxin containing pokeweed antiviral protein." 01/01/1985 - "Leukemia cells were mixed with normal human bone marrow cells to simulate bone marrow from leukemia patients; the mixture was then treated with a combination of stabilized derivative of cyclophosphamide [Mafosfamide (ASTA Z 7557)] and pokeweed antiviral protein-containing immunotoxin. " 04/01/1984 - "Prevention of growth of leukemia cells in mice by monoclonal antibodies directed against Thy 1.1 antigen disulfide linked to two ribosomal inhibitors:pokeweed antiviral protein or ricin A chain." 02/15/1991 - "We describe a standardized method for the preparation and purification of a potent immunotoxin against B-lineage leukemia/lymphoma cells, constructed with the ribosome inhibitory single chain plant toxin pokeweed antiviral protein (PAP) and a murine IgG1 monoclonal antibody (MoAb) specific for the human B lineage differentiation antigen CD19 for human clinical trials. "
4.	Lymphoma (Lymphomas) 02/15/1991 - "We describe a standardized method for the preparation and purification of a potent immunotoxin against B-lineage leukemia/lymphoma cells, constructed with the ribosome inhibitory single chain plant toxin pokeweed antiviral protein (PAP) and a murine IgG1 monoclonal antibody (MoAb) specific for the human B lineage differentiation antigen CD19 for human clinical trials. "
5.	Infections 01/01/2013 - "Inhibition of Japanese encephalitis virus infection in vitro and in vivo by pokeweed antiviral protein." 10/01/1990 - "Infection of HeLa cells with poliovirus results in cell permeabilization to pokeweed antiviral protein. " 10/01/2015 - "Pokeweed antiviral protein restores levels of cellular APOBEC3G during HIV-1 infection by depurinating Vif mRNA." 09/01/2000 - "A non-toxic pokeweed antiviral protein mutant inhibits pathogen infection via a novel salicylic acid-independent pathway."

Related Drugs and Biologics

1.	Immunotoxins (Immunotoxin)
2.	Proteins (Proteins, Gene)
3.	Antiviral Agents (Antivirals)
4.	Monoclonal Antibodies
5.	Immunoglobulin G (IgG)
6.	Differentiation Antigens
7.	Ricin
8.	Saporins
9.	momordin
10.	Gelonium multiflorum GEL protein

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)