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pazelliptine
RN given refers to parent cpd; structure given in first source
Also Known As:
1-gamma-diethylaminopropylamino-5-methyl-dipyrido (4,3-b)(3,4-f)indole; 10-(3-diethylaminopropylamino)-6-methyl-5H-pyrido(3',4'-4,5)pyrrolo(2,3-g)isoquinoline; BD 40; BD-40; DAPA-PPI; pazelliptine maleate (1:3); N,N-diethyl-N'-(6-methyl-5H-pyrido(3',4'-4,5)pyrrolo(2,3-g)isoquinolin-10-yl)-1,3-propanediamine
Networked:
7
relevant articles (
1
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Heterocyclic Compounds: 198
Fused-Ring Heterocyclic Compounds
2-Ring Heterocyclic Compounds
Indoles: 200
pazelliptine: 7
Isoquinolines: 34
pazelliptine: 7
Experts
1.
Dunne, C
: 1 article (12/2007)
2.
Kay, E
: 1 article (12/2007)
3.
Leader, M
: 1 article (12/2007)
4.
Murphy, G M
: 1 article (12/2007)
5.
O'Grady, A
: 1 article (12/2007)
6.
O'Kelly, P
: 1 article (12/2007)
Related Diseases
1.
Pathologic Complete Response
10/01/1996 - "
A significant increase of sTM levels compared with control values (26 +/- 2 ng/ml) was found in active WG, TA, GCA, PAN, and BD: limited active WG: 63 +/- ng/ml; generalized active WG: 119 +/- 15 ng/ml; limited WG, partial remission: 60 +/- 5 ng/ml; generalized WG, partial remission: 75 +/- 7 ng/ml; active TA: 36 +/-; active GCA: 36 +/- 4 ng/ml, active PAN: 33 +/- 2 ng/ml, active BD: 40 +/- 4 ng/ml. Limited and generalized WG in complete remission did not have elevated levels of sTM.
"
2.
Neoplasms (Cancer)
02/15/1997 - "
Low light level fluorescence microscopy studies have been carried out on MCF7-P human mammary tumor cells to localize the intracellular distribution of two new anticancer drugs, Pazelliptine and Intoplicine, which are currently under clinical evaluation.
"
05/01/1994 - "
In the follow-up study reported here, the activities of cisplatin, AZQ (diaziquone), pazelliptine and retelliptine have been evaluated against a panel of 40 established tumor lines grown subcutaneously in nude mice.
"
09/01/1984 - "
BD-40 is a pyrido-pyrrolo-isoquinoline analogue of ellipticine, which possesses oncostatic in vivo activity on experimental tumors, and dose-dependent cytostatic and cytotoxic activities on mammalian cells in culture.
"
05/01/1994 - "
When activity was defined as a specific growth delay > 1 and a tumor growth inhibition > 50%, then cisplatin demonstrated activity in 15 of 40 xenografts tested (3 of 5 breast, 1 of 6 colon, 0 of 5 head+neck, 2 of 6 NSCLC, 4 of 7 SCLC, 1 of 5 melanoma and 4 of 6 ovarian cancers); AZQ was active in 23 of 38 xenografts (2 of 3 breast, 2 of 7 colon, 4 of 5 head+neck, 3 of 6 NSCLC, 6 of 6 SCLC, 2 of 5 melanoma, 4 of 6 ovarian cancers); pazelliptine was active in 2 of 38 xenografts (1 of 5 breast cancers, 1 of 5 melanoma) while retelliptine was active in 1 of 39 xenografts (a breast cancer xenograft) tested.
"
3.
Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/01/2007 - "
A study of 11 normal skin, 29 Bowen's disease (BD), 40 squamous cell carcinoma (SCC) and 38 basal cell carcinoma (BCC) samples for MMP-2, MMP-9, TIMP-1 and TIMP-2 expression was carried out using immunohistochemistry and in situ hybridization.
"
4.
Basal Cell Carcinoma (Rodent Ulcer)
12/01/2007 - "
A study of 11 normal skin, 29 Bowen's disease (BD), 40 squamous cell carcinoma (SCC) and 38 basal cell carcinoma (BCC) samples for MMP-2, MMP-9, TIMP-1 and TIMP-2 expression was carried out using immunohistochemistry and in situ hybridization.
"
5.
Bowen's Disease (Disease, Bowen)
12/01/2007 - "
A study of 11 normal skin, 29 Bowen's disease (BD), 40 squamous cell carcinoma (SCC) and 38 basal cell carcinoma (BCC) samples for MMP-2, MMP-9, TIMP-1 and TIMP-2 expression was carried out using immunohistochemistry and in situ hybridization.
"
Related Drugs and Biologics
1.
Tissue Inhibitor of Metalloproteinase-2
2.
Tissue Inhibitor of Metalloproteinase-1
3.
intoplicine
4.
ellipticine
5.
Cytostatic Agents
6.
Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)
7.
Cisplatin (Platino)
8.
BR 76 (BR 1376)
9.
retelliptine (BD 84)
10.
isoquinoline