naloxazone

has high affinity for opiate receptor binding sites; structure given in first source

Also Known As:

naloxone-6-hydrazone; Morphinan-6-one, 4,5-epoxy-3,14-dihydroxy-17-(2-propenyl)-, hydrazone, (5alpha)-

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

1.	Catalepsy 10/08/1982 - "Rats whose high affinity (mu 1) sites had been blocked with naloxazone 24 h earlier, on the other hand, showed no evidence of catalepsy (P less than 0.01). " 06/16/1983 - "Pretreatment with naloxazone significantly blocked morphine analgesia, catalepsy and hypothermia at a dose which completely eliminated high-affinity binding in brain membranes. "
2.	Hypothermia 06/16/1983 - "Pretreatment with naloxazone significantly blocked morphine analgesia, catalepsy and hypothermia at a dose which completely eliminated high-affinity binding in brain membranes. "
3.	Endotoxemia 05/06/1983 - "Unlike other less selective opiate antagonists such as naloxone, naloxazone failed to block or reverse the hemodynamic effects of endotoxemia. "
4.	Shock 05/06/1983 - "Cardiovascular effects of the high affinity, irreversible opiate antagonist, naloxazone, were investigated in conscious rats subjected to endotoxic shock. " 05/06/1983 - "However, naloxazone pretreatment prevented the usual therapeutic effects of naloxone in endotoxic shock. " 05/06/1983 - "Naloxazone lacks therapeutic effects in endotoxic shock yet blocks the effects of naloxone."
5.	Respiratory Insufficiency (Respiratory Failure) 06/16/1983 - "Moreover, naloxazone significantly attenuated the morphine-induced hypotension and respiratory depression, whereas morphine-induced bradycardia was less affected. "

1.	Morphine (MS Contin)
2.	Naloxone (Narcan)
3.	Opioid Analgesics (Opioids)
4.	Opiate Alkaloids
5.	Therapeutic Uses
6.	mu Opioid Receptors (mu Opioid Receptor)
7.	morphiceptin