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timiperone
structure
Also Known As:
4'-fluoro-4-(4-(2-thioxo-1-benzimidazolinyl)piperidino)butyrophenone; DD 3480; 4-(4-(2,3-dihydro-2-thioxo-1H-benzimidazol-1-yl)-1-piperidinyl)-1-(4-fluorophenyl)-1- butanone
Networked:
8
relevant articles (
5
outcomes,
2
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Organic Chemicals: 133
Ketones: 2618
Butyrophenones: 43
timiperone: 8
Related Diseases
1.
Schizophrenia (Dementia Praecox)
01/01/1982 - "
Comparison of efficacy of a new butyrophenone derivative, timiperone and perphenazine in schizophrenia by a multicentre controlled study.
"
01/01/1983 - "
Comparison of efficacy of timiperone, a new butyrophenone derivative, and clocapramine in schizophrenia: a multiclinic double-blind study.
"
01/01/1982 - "
The efficacy of timiperone in schizophrenia as compared with perphenazine was assessed in a double-blind fashion in 205 patients throughout a 12-week treatment period.
"
01/01/1983 - "
The efficacy and safety of timiperone, a new butyrophenone derivative, in schizophrenia as compared with haloperidol were assessed in a multi-clinic double-blind controlled study in a total of 206 patients.
"
01/01/1983 - "
The clinical efficacy and safety of timiperone, a new butyrophenone derivative, on chronic schizophrenia was compared with clocapramine by the double-blind method using a total of eighty-eight patients, consisting of forty-four patients in each group.
"
2.
Vomiting
01/01/1985 - "
[Prophylactic efficacy of timiperone (Tolopelon) in vomiting caused by DDP].
"
09/01/1986 - "
Five patients under 45 years old given Timiperone 6 mg/day by the same method had few episodes of vomiting, but suffered from extrapyramidal symptoms.
"
09/01/1986 - "
Finally 6 patients undergoing DDP with Timiperone in combination with trihexyphenidyl suffered no symptoms of catalepsy but sometimes had mild vomiting episodes (1-4 times a day).
"
09/01/1989 - "
[Antiemetic efficacy of intravenous timiperone in emesis induced by a 5-day-course of cisplatin].
"
09/01/1986 - "
[Antiemetic therapy with timiperone in cisplatin-induced vomiting].
"
3.
Neoplasms (Cancer)
09/01/1986 - "
Nineteen patients with urologic malignancy undergoing chemotherapy with cisplatin in combination with other agents were studied for the antiemetic efficacy of Timiperone.
"
4.
Nausea
01/01/1983 - "
In the over-all safety rating, there were no significant differences between the two groups, but in accompanying symptoms and side-effects, timiperone showed significantly less tendency than clocapramine in dyskinesia, insomnia, constipation and nausea.
"
09/01/1986 - "
We would like to propose that in antiemetic therapy with Timiperone for cisplatin-induced nausea and vomiting, a dose of 4.5 mg/day be given from two days before undergoing chemotherapy because of the cumulative effect of Timiperone.
"
5.
Hallucinations (Hallucination)
01/01/1983 - "
Timiperone showed a higher improvement rate than clocapramine in hallucination and disturbance of self-consciousness.
"
01/01/1983 - "
With regard to analysis by stratification timiperone was superior to haloperidol in improving abnormal experiences such as hallucination and delusion as well as deficiency of initiative and blunted affect.
"
Related Drugs and Biologics
1.
Cisplatin (Platino)
2.
Antiemetics
3.
Perphenazine (Trilafon)
4.
3-chlorocarpipramine (clocapramine)
5.
Haloperidol (Haldol)
6.
Antipsychotic Agents (Antipsychotics)
7.
Trihexyphenidyl (Artane)
8.
Porphyrins
9.
Methylprednisolone
Related Therapies and Procedures
1.
Drug Therapy (Chemotherapy)
2.
Therapeutics