pycnogenols

Pycnogenol (tradename) is a commercial mixture of bioflavonoids with antioxidative properties; isolated from the bark of the French marine pine Pinus pinaster or Pinus maritima; term suggested to designate flavan-3-ol derivatives

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Networked: 181 relevant articles (44 outcomes, 74 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Belcaro, G: 24 articles (09/2017 - 10/2004)
2.	Dugall, M: 24 articles (09/2017 - 10/2004)
3.	Cesarone, M R: 21 articles (09/2017 - 10/2004)
4.	Ippolito, E: 19 articles (02/2015 - 10/2004)
5.	Hosoi, M: 17 articles (09/2017 - 11/2005)
6.	Ricci, A: 16 articles (09/2017 - 10/2004)
7.	Rohdewald, P: 16 articles (09/2010 - 01/2001)
8.	Ledda, A: 15 articles (09/2017 - 11/2005)
9.	Cacchio, M: 15 articles (06/2014 - 07/2005)
10.	Pellegrini, L: 13 articles (09/2017 - 07/2005)

Related Diseases

1.	Edema (Dropsy) 04/01/2006 - "At the end of the study, microcirculatory results indicated: a progressive decrease of skin flux at rest (RF); a significant decrease in capillary filtration (RAS); an improvement in the symptomatic venous score (ASLS); a reduction in edema; a significant improvement (increase) in pO(2) and a decrease in pCO(2) in the Pycnogenol group. " 10/01/2006 - "At 4 and 8 weeks, in all Pycnogenol-treated subjects, microcirculatory and clinical evaluations indicated a progressive decrease in skin flux, indicating an improvement in the level of microangiopathy; a significant decrease in capillary filtration; a significant improvement in the symptomatic score; and a reduction in edema. " 10/01/2000 - "Pycnogenol significantly improved the legs' heaviness and subcutaneous edema; the venous pressure was also significantly reduced by the Pycnogenol treatment, thus adding further clinical evidence to its therapeutic efficacy in patients with CVI. " 11/01/2005 - "Oral Pycnogenol is effective in venous disease and particularly in controlling edema. " 10/26/2017 - "The effect of Pycnogenol was further confirmed via histopathological examination of cardiac tissues, which suggests that, it considerably improved the injury related to tissue damage through suppression of edema and infiltration of neutrophil compared to IRI group. "
2.	Inflammation (Inflammations) 11/01/2016 - "Pycnogenol Ameliorates Asthmatic Airway Inflammation and Inhibits the Function of Goblet Cells." 06/01/2022 - "Pycnogenol (PYC) is a natural compound that could control inflammation and oxidative stress. " 02/11/2020 - "We expect that supplementation of 150 mg pycnogenol for 10 days will improve clinical and nutritional status and reduce the inflammation and oxidative stress of the TBI patients. " 02/11/2020 - "One of the ingredients that can be used in immunonutrition formulas to reduce inflammation and oxidative stress is pycnogenol. " 01/01/2018 - "Corrigendum to "Inhibitory Effect of a French Maritime Pine Bark Extract-Based Nutritional Supplement on TNF-α-Induced Inflammation and Oxidative Stress in Human Coronary Artery Endothelial Cells"."
3.	Pain (Aches) 06/01/2020 - "At 8 weeks, the pain score was lower with Pycnogenol in comparison with SM (P<0.05). " 08/01/2008 - "Following treatment with Pycnogenol patients reported an improvement of WOMAC index (p < 0.05), and a significant alleviation of pain by visual analogue scale (p < 0.04), the placebo had no effect. " 03/01/2006 - "These results indicate the potential of Pycnogenol to reduce pain associated with pregnancy." 03/01/2006 - "Pycnogenol alleviates pain associated with pregnancy." 10/01/2004 - "The number of days with pain was significantly lower (p < 0.01) in the second cycle of treatment with Pycnogenol. "
4.	Atherosclerosis 10/01/1998 - "Pycnogenol (P) is purported to exhibit effects that could be beneficial in terms of prevention of chronic age-related diseases such as atherosclerosis. " 10/23/2015 - "Pycnogenol attenuates atherosclerosis by regulating lipid metabolism through the TLR4-NF-κB pathway." 07/01/2012 - "However, the effects of Pycnogenol on endothelial dysfunction, a precursor of atherosclerosis and cardiovascular events, remain still elusive. " 05/01/2001 - "In total, 40 patients with diabetes, atherosclerosis and other vascular diseases involving the retina were enrolled; 30 of them were treated with Pycnogenol and 10 with placebo. " 02/01/2014 - "The aim of the study was to evaluate the effect of the nutritional supplements Pycnogenol and TECA (total triterpenic fraction of Centella Asiatica) on atherosclerosis progression in low-risk asymptomatic subjects with carotid or femoral non-stenosing plaques. "
5.	Venous Insufficiency 03/01/2014 - "Improvements of venous tone with pycnogenol in chronic venous insufficiency: an ex vivo study on venous segments." 09/01/2010 - "Improvement of signs and symptoms of chronic venous insufficiency and microangiopathy with Pycnogenol: a prospective, controlled study." 10/01/2006 - "In conclusion, this study confirms the fast clinical efficacy of Pycnogenol in patients with chronic venous insufficiency and venous microangiopathy. " 10/01/2006 - "The aim of this study was to investigate the clinical efficacy of oral Pycnogenol (Horphag Research Ltd, UK) in patients with severe chronic venous insufficiency. " 09/01/2011 - "Pycnogenol for chronic venous insufficiency."

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Related Therapies and Procedures

1.	Therapeutics
2.	Enteral Nutrition (Feeding, Tube)
3.	Drug Therapy (Chemotherapy)
4.	Compression Stockings
5.	Chemoprevention