tiotidine

UD gives slightly different structure for this cpd; RN given refers to parent cpd; structure in first source

Also Known As:

2-guanidino-4-(2-(2-cyano-3-methylguanidino)ethylthiomethyl)thiazole; ICI 125,211; tiotidine monofumarate; tiotidine monohydrochloride; tiotidine monomaleate; tiotidine monotartrate, ((R,R)-(+))-isomer; N-(2-(((2-((aminoiminomethyl)amino)-4-thiazoyl) methyl)thio)ethyl)-N'-cyano-N''-methylguanidine

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Related Diseases

1.	Duodenal Ulcer (Curling's Ulcer) 05/01/1981 - "The efficacy of tiotidine, a new H2-receptor antagonist, in reducing nocturnal acid secretion of duodenal ulcer patients (N = 12, ages 21-60 years) was investigated. " 05/01/1981 - "Tiotidine, a new H2-receptor antagonist, is a potent inhibitor of nocturnal acid secretion in duodenal ulcer patients." 02/01/1981 - "The effects of tiotidine, a new histamine H2-receptor antagonist, and cimetidine on food-stimulated gastric acid secretion were evaluated in duodenal ulcer patients. "
2.	Carcinoma (Carcinomatosis) 01/01/1988 - "Studies with the first drug, ICI 125,211, elicited dysplasia/carcinoma lesions in 17 of 828 treated rats with 12 of the 17 lesions occurring in the pyloric region of the stomach. "
3.	Neoplasm Metastasis (Metastasis) 12/15/1990 - "A single dose of any of the H2R antagonists ranitidine, tiotidine, famotidine, or cimetidine drastically augmented metastasis. "

Related Drugs and Biologics

1.	Acids
2.	Cimetidine (Biomet)
3.	Famotidine (Pepcid)
4.	Ranitidine (Zantac)
5.	Histamine (Histamine Dihydrochloride)