ferric citrate iron reductase (ferric-chelate reductase)

requires FMN, uses NADH; FRE1 (GenBank M86908) and FRE2 (GenBank Z28220) provide membrane-associated ferric reductase activity for Saccharomyces cerevisiae; most ferric reductases are flavin reductases (NAD(P)H-FLAVIN OXIDOREDUCTASE) - BioMetals 7:3-8; 1994

Also Known As:

ferric-chelate reductase; AtFRO6 protein, Arabidopsis; FRE1 protein, S cerevisiae; FRE2 protein, S cerevisiae; FRO1 protein, tomato; FRO2 protein, Arabidopsis; FRO6 protein, Arabidopsis; FeCitR; NADH-Fe(III)-chelate reductase; NADH-dependent ferric-chelate reductase; NADH-dependent iron(III)-chelate reductase; NFR enzyme; YKL220C protein, S cerevisiae; YLR214W protein, S cerevisiae; ferric iron reductase; ferric reductase; ferric reductase, NADH-dependent; ferric-chelate reductase 1, S cerevisiae; ferric-chelate reductase 2, S cerevisiae; ferrireductase; iron (III) reductase; iron reductase

Networked: 54 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Oxidoreductases: 13671
    - Oxidoreductases Acting on CH-NH Group Donors
      - FMN Reductase: 4
        ferric citrate iron reductase: 54

Experts

1.	McKie, Andrew T: 3 articles (11/2012 - 09/2003)
2.	Simpson, Robert J: 3 articles (11/2012 - 01/2005)
3.	Amson, Robert: 2 articles (03/2015 - 12/2011)
4.	Telerman, Adam: 2 articles (03/2015 - 12/2011)
5.	Du, Juan: 2 articles (03/2013 - 03/2008)
6.	Ling, Hong-Qing: 2 articles (03/2013 - 03/2008)
7.	Wang, Ning: 2 articles (03/2013 - 03/2008)
8.	Wu, Huilan: 2 articles (03/2013 - 03/2008)
9.	Yuan, Youxi: 2 articles (03/2013 - 03/2008)
10.	Latunde-Dada, Gladys O: 2 articles (11/2012 - 02/2009)

Related Diseases

1.	Parkinson Disease (Parkinson's Disease) 12/01/2017 - "Furthermore, studies on tissue from Parkinson's disease patient brains showed a significant decrease in ferrireductase activity, possibly due to deposition of large amounts of inactive protein. " 01/01/2020 - "Therefore, the ferrireductase alpha-synuclein may hold the key for major pathology of Parkinson's disease. " 01/01/2020 - "The role of alpha-synuclein as ferrireductase in neurodegeneration associated with Parkinson's disease." 12/01/2017 - "Alpha-synuclein ferrireductase activity is detectible in vivo, is altered in Parkinson's disease and increases the neurotoxicity of DOPAL."
2.	Epilepsy (Aura) 01/01/2017 - "Recent proteomic studies have identified that Ferric Chelate Reductase 1 Like protein (FRRS1L), whose mutations in human lead to epilepsy, choreoathetosis, and cognitive deficits, is present in native AMPAR complexes in the brain. "
3.	Iron Deficiencies 10/04/2014 - "Northern blot analysis was used to examine ferric reductase genes expression levels in different iron deficiency. " 01/01/2013 - "We demonstrate that PrPC is a ferrireductase (FR), and its absence causes systemic iron deficiency in PrP knock-out mice (PrP-/-). " 12/01/2008 - "Iron deficiency-induced increase of root branching contributes to the enhanced root ferric chelate reductase activity." 01/01/2008 - "[Mutational reconstructed ferric chelate reductase confers enhanced tolerance in rice to iron deficiency in calcareous soil]." 12/01/2007 - "The activity of the root ferric-chelate reductase and the proliferation of root hairs induced by iron deficiency were stimulated by NO supplementation and suppressed by NO scavenging. "
4.	Hypochromic Anemia (Chlorosis) 08/01/2011 - "Overexpression of AtFRO6 in transgenic tobacco enhances ferric chelate reductase activity in leaves and increases tolerance to iron-deficiency chlorosis." 10/01/2019 - "NH4+ also increases soluble Fe levels in shoots by upregulating genes involved in Fe translocation, such as FRD3 (FERRIC REDUCTASE DEFECTIVE3) and NAS1 (NICOTIANAMINE SYNTHASE1), hence, alleviating leaf chlorosis. " 10/01/2006 - "The enhanced ferric reductase activity led to reduced chlorosis, increased chlorophyll concentration and a lessening in biomass loss in the transgenic events between Fe treatments as compared to control plants grown under hydroponics that mimicked Fe-sufficient and Fe-deficient soil environments. " 05/01/2016 - "Lesion of CIPK23 rendered Arabidopsis mutants hypersensitive to iron deficiency, as evidenced by stronger chlorosis in young leaves and lower iron concentration than wild-type plants under iron-deficient conditions by down-regulating ferric chelate reductase activity. " 08/01/2011 - "These results suggest that FRO6 functions as a ferric chelate reductase for iron uptake by leaf cells, and overexpression of AtFRO6 in transgenic plants can reduce iron deficiency chlorosis."
5.	Starvation 01/01/1996 - "Both species showed increased ferric reductase activity upon Fe starvation, but they differed in the maximum rates. " 11/01/2011 - "FreB-inactivation by gene deletion was phenotypically largely inconspicuous unless combined with inactivation of the siderophore system, which then decreased growth rate, surface ferrireductase activity and oxidative stress resistance during iron starvation. " 09/01/1998 - "The uptake of Fe was stimulated two- to threefold by deferoxamine, but this increment could be abolished by copper starvation or inhibition of the ferric reductase by Pt, indicating that Fe solubilized by this molecule also entered the reductive iron uptake pathway."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Iron
3.	alpha-Synuclein
4.	Transcription Factors (Transcription Factor)
5.	Oxidoreductases (Dehydrogenase)
6.	Proton-Translocating ATPases (ATPase, H+)
7.	Chlorophyll
8.	metal transporting protein 1 (ferroportin)
9.	ferric citrate iron reductase (ferric-chelate reductase)
10.	Basic Helix-Loop-Helix Transcription Factors

Related Therapies and Procedures

1.	Therapeutics