|1.||Iwasaki, Motoki: 3 articles (05/2010 - 09/2008)|
|2.||Tsugane, Shoichiro: 3 articles (05/2010 - 09/2008)|
|3.||Itoh, Hiroaki: 3 articles (05/2010 - 09/2008)|
|4.||Matsumura, Fumio: 3 articles (01/2007 - 01/2002)|
|5.||Sasazuki, Shizuka: 2 articles (05/2010 - 09/2008)|
|6.||Tremblay, Angelo: 2 articles (05/2010 - 03/2002)|
|7.||Inoue, Manami: 2 articles (05/2010 - 09/2008)|
|8.||Brock, John W: 2 articles (11/2007 - 02/2003)|
|9.||Zou, Enmin: 2 articles (09/2003 - 01/2002)|
|10.||Koifman, Rosalina Jorge: 1 article (01/2015)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2007 - "Based upon these results, it was concluded that beta-HCH does act as a breast cancer promoter which exerts its tumorigenic activity via increased c-Neu expression."
01/01/2007 - "Promotion of breast cancer by beta-hexachlorocyclohexane in MCF10AT1 cells and MMTV-neu mice."
09/01/2003 - "Our results provide the in vitro mechanistic basis supporting the hypothesis that beta-HCH is one of the epigenetic risk factors assisting the progression of breast cancer cells to an advanced state of malignancy."
11/15/1990 - "After adjusting for age and parity by stepwise logistic regression, beta-HCH remained a significant risk factor of breast cancer. "
11/15/1990 - "Occurrence of beta-hexachlorocyclohexane in breast cancer patients."
01/01/2007 - "In our in vivo studies, MMTV-Neu mice were injected with beta-HCH and observed for tumor formation over a 70 week period. "
01/01/2007 - "In this current study, we decided to investigate the long-term effects of beta-HCH in both the MCF10AT1 cell line which was derived from a normal epithelial cell line by stably transfecting a mutated c-Ha-ras and a MMTV-Neu mouse model for mammary cancer in vivo. "
01/01/2007 - "To demonstrate beta-HCH's tumorigenic properties in an in vivo system, we used an MMTV-Neu mouse model.MMTV-Neu is a c-Neu overexpressing strain which has been shown to spontaneously develop mammary tumors at later stages of aging. "
09/01/2003 - "An epidemiological study has indicated that exposure to beta-HCH could be one of the significant environmental risk factors for the development of human breast cancers. "
07/01/1998 - "The concentrations of beta-HCH, PCB no. 156 and 170 were lower (not significant) in cancer tissue than in tissue from women with benign disease. "
|3.||Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell)
|4.||Prostatic Neoplasms (Prostate Cancer)
05/01/2010 - "No statistically significant association with total prostate cancer was seen for any plasma organochlorine, although we did observe an insignificant inverse association for plasma HCB and beta-HCH. "
01/01/2010 - "After adjustment for other covariates, serum concentrations of beta-hexachlorocyclohexane (HCH) (p for trend = 0.02), trans-nonachlor (p for trend = 0.002), and dieldrin (p for trend = 0.04) were significantly associated with the risk of prevalent prostate cancer. "
03/01/2001 - "In the human prostate cancer cell lines LNCaP and PC-3, erbB-2 kinase was activated by pesticides of different chemical classes: (1) the organochlorine insecticides beta-hexa-chlorocyclohexane (beta-HCH), o,p'-dichlorodiphenyltrichloroethane (o,p'-DDT), and heptachlor epoxide; (2) the pyrethroid insecticide trans-permethrin, and (3) the fungicide chlorothalonil. "
05/01/2010 - "We used a conditional logistic regression model to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for prostate cancer in relation to plasma levels of nine organochlorines: PCBs, dichlorodiphenyltrichloroethane (DDT), hexachlorobenzene (HCB), beta-hexachlorocyclohexane (beta-HCH), trans- and cis-nonachlor, oxychlordane, and mirex. "
|5.||Body Weight (Weight, Body)
03/01/1997 - "The initial 3-day treatment with either beta-HCH or o,p'-DDT doubled the relative dry weight of the uterus: 102 +/- 8.6 mg/kg body weight (BW) and 104 +/- 4.4 mg/kg BW for beta-HCH and o,p'-DDT, respectively, compared to 49 +/- 1.9 mg/kg BW for vehicle-treated animals. "
01/01/1992 - "Covariance analysis and log-linear models revealed correlation between increasing age and blood concentrations of HCB, beta-HCH, DDE and OCS, between relative body weight and HCB or DDE, between locality and all pollutants analyzed, and, finally, between fish consumption and OCS and Hg. Regarding the influence of locality on the body burden of pollutants it may be assumed that additional routes of uptake, e.g., via drinking water or air, might be important."
08/01/1988 - "Mice exposed to 0, 100, or 300 mg of beta-HCH/kg of diet were evaluated for changes in ovarian and uterine histology, body weight, lymphoid organ weight and histology, splenic cellularity, antigen-specific IgM and IgG plaque-forming cells (PFC), proliferative responses to mitogens, natural killer (NK) cell activity, and induction of cytolytic T lymphocytes. "
|1.||Dichlorodiphenyl Dichloroethylene (DDE)
|5.||Polychlorinated Biphenyls (PCBs)
|10.||Protein-Tyrosine Kinases (Tyrosine Kinase)