hydrangenol

12/01/2023 - "In this study, we investigated the protective effects of hydrangenol (HG) against lipopolysaccharide (LPS)-induced endotoxemia and elucidated the underlying molecular mechanisms of action in C57BL/6 mice. "
12/01/2023 - "Protective effect of hydrangenol on lipopolysaccharide-induced endotoxemia by suppressing intestinal inflammation."

07/31/2023 - "and its bioactive compound, hydrangenol, are reported to have anti-inflammatory effects, but few studies have investigated the effects of hydrangenol in colitis. "
07/31/2023 - "To investigate the anti-colitic effects of hydrangenol, DSS-induced colitis mice, HT-29 colonic epithelial cells treated with supernatant from LPS-inflamed THP-1 macrophages, and LPS-induced RAW264.7 macrophages were used. "
07/31/2023 - "Oral administration of hydrangenol (15 or 30 mg kg-1) significantly alleviated DSS-induced colitis by preventing DAI scores, shortening colon length, and colonic structural damage. "
07/31/2023 - "Taken together, our findings suggest that hydrangenol recovers the tight junction proteins and down-regulates the expression of the pro-inflammatory mediators by interfering with the macrophage infiltration in DSS-induced colitis. "
07/31/2023 - "Hydrangenol, an active constituent of Hydrangea serrata (Thunb.) Ser., ameliorates colitis through suppression of macrophage-mediated inflammation in dextran sulfate sodium-treated mice."

07/31/2023 - "Hydrangenol, an active constituent of Hydrangea serrata (Thunb.) Ser., ameliorates colitis through suppression of macrophage-mediated inflammation in dextran sulfate sodium-treated mice."
12/01/2023 - "Protective effect of hydrangenol on lipopolysaccharide-induced endotoxemia by suppressing intestinal inflammation."

01/01/2018 - "However, there have been few studies on the effect of hydrangenol on oncogenesis. "
05/15/1998 - "The effects of two naphthoquinones, juglone and plumbagin, and an isocoumarin, hydrangenol, on intestinal carcinogenesis in rats were examined by dietary exposure during the initiation phase. "

05/15/1998 - "Hydrangenol tended to decrease the incidence and the multiplicity of tumors in the entire intestine induced by AOM, but the effect was not statistically significant. "
01/01/2018 - "In this study, we evaluated the anti-cancer activity of hydrangenol against the EJ bladder cancer cell line. "