bursehernin

a dibenzylbutyrolactone found in PODOPHYLLIN; analog of podorhizol; RN & N1 from CA Vol 90 Form Index; structure in first source

Also Known As:

(3R-trans)-4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl)methyl)dihydro-2(3H)-furanone; 2(3H)-Furanone, 4-(1,3-benzodioxol-5-ylmethyl)-3-((3,4-dimethoxyphenyl)methyl)dihydro-, (3R-trans)-

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Benzene Derivatives: 17
        Benzyl Compounds: 2
        Lignans: 1113
        bursehernin: 4
- Lactones: 1549
  - bursehernin: 4

Experts

1.	Graidist, Potchanapond: 2 articles (09/2019 - 01/2017)
2.	Tedasen, Aman: 2 articles (09/2019 - 01/2017)
3.	Rattanaburee, Thidarath: 1 article (09/2019)
4.	Sukpondma, Yaowapa: 1 article (09/2019)
5.	Thongpanchang, Tienthong: 1 article (09/2019)
6.	Wongma, Krittaphat: 1 article (09/2019)
7.	Choomwattana, Saowapak: 1 article (01/2017)
8.	Tipmanee, Varomyalin: 1 article (01/2017)
9.	Chapuis, Jean-Charles: 1 article (02/2004)
10.	Doubek, Dennis L: 1 article (02/2004)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "This study suggests that bursehernin has potential for development as an anti-tumor agent with an anti-proliferation, and cell cycle arrest inducing, although further studies are needed." 01/01/2017 - "In this study, the binding-inhibitory effects of bursehernin were screening on selected 80 proteins associated with cancer pathway. " 01/01/2017 - "Structure-guided cancer blockade between bioactive bursehernin and proteins: Molecular docking and molecular dynamics study." 09/01/2019 - "Anticancer activity of synthetic (±)-kusunokinin and its derivative (±)-bursehernin on human cancer cell lines." 01/01/2017 - "Bursehernin (5'-desmethoxyyatein) is a natural lignan, which has anti-tumor activity in vitro. "
2.	Cholangiocarcinoma 09/01/2019 - "The result showed that (±)-kusunokinin and (±)-bursehernin represented the strongest growth inhibition against breast cancer (MCF-7) and cholangiocarcinoma (KKU-M213) cells with the IC50 values of 4.30 ± 0.65 μM and 3.70 ± 0.79 μM, respectively, both of which were lower than IC50 of normal fibroblast cells (L929). " 09/01/2019 - "In this study, (±)-kusunokinin and its derivative, (±)-bursehernin, were synthesized and investigated for their anticancer activities on cell viability, cell cycle arrest and apoptosis in cancer cell lines including breast cancer (MCF-7, MDA-MB-468 and MDA-MB-231), colon cancer (HT-29) and cholangiocarcinoma (KKU-K100, KKU-M213 and KKU-M055) cells. "
3.	Colonic Neoplasms (Colon Cancer) 09/01/2019 - "In this study, (±)-kusunokinin and its derivative, (±)-bursehernin, were synthesized and investigated for their anticancer activities on cell viability, cell cycle arrest and apoptosis in cancer cell lines including breast cancer (MCF-7, MDA-MB-468 and MDA-MB-231), colon cancer (HT-29) and cholangiocarcinoma (KKU-K100, KKU-M213 and KKU-M055) cells. "
4.	Breast Neoplasms (Breast Cancer) 09/01/2019 - "The result showed that (±)-kusunokinin and (±)-bursehernin represented the strongest growth inhibition against breast cancer (MCF-7) and cholangiocarcinoma (KKU-M213) cells with the IC50 values of 4.30 ± 0.65 μM and 3.70 ± 0.79 μM, respectively, both of which were lower than IC50 of normal fibroblast cells (L929). " 09/01/2019 - "In this study, (±)-kusunokinin and its derivative, (±)-bursehernin, were synthesized and investigated for their anticancer activities on cell viability, cell cycle arrest and apoptosis in cancer cell lines including breast cancer (MCF-7, MDA-MB-468 and MDA-MB-231), colon cancer (HT-29) and cholangiocarcinoma (KKU-K100, KKU-M213 and KKU-M055) cells. "
5.	Lymphoid Leukemia 02/01/2004 - "Bioassay (P388 lymphocytic leukemia cell line and human tumor cell lines)-guided separation of the extracts prepared from the tropical and coastal trees Hernandia peltata (Malaysia) and Hernandianymphaeifolia (Republic of Maldives) led to the isolation of a new lignan designated as hernanol (1) and 12 previously known lignans: (-)-deoxypodophyllotoxin (2), deoxypicropodophyllin (3), (+)-epiaschantin (4), (+)-epieudesmin (5), praderin (6), 5'-methoxyyatein (7), podorhizol (8), deoxypodorhizone (9), bursehernin (10), kusunokinol (11), clusin (12), and (-)-maculatin (13). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	kusunokinin
3.	Lignans
4.	Mitogen-Activated Protein Kinase Kinases (MEKs)
5.	Tubulin
6.	Phosphotransferases (Kinase)
7.	Heat-Shock Proteins (Heat-Shock Protein)
8.	Adenylyl Cyclases (Adenylyl Cyclase)
9.	hernanol
10.	matairesinol