enpiroline

structure

Also Known As:

WR 180409; WR-180,409; WR-180409; threo-alpha-(2-piperidyl)-2-trifluoromethyl-6-(4-trifluoromethylphenyl)- 4-pyridinemethanol phosphate; 4-Pyridinemethanol, alpha-2-piperidinyl-2-(trifluoromethyl)-6-(4-(trifluoromethyl)phenyl)-, (R*,R*)-(+-)-, phosphate (1:1) (salt)

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyridines: 88
    - enpiroline: 5

Experts

1.	Ellis, William: 2 articles (09/2013 - 06/2012)
2.	Ingram, Katrin: 2 articles (09/2013 - 06/2012)
3.	Keiser, Jennifer: 2 articles (09/2013 - 06/2012)
4.	Duthaler, Urs: 1 article (09/2013)
5.	Vargas, Mireille: 1 article (09/2013)

Related Diseases

1.	Infections 09/01/1984 - "Evaluation of the 4-pyridinemethanol WR 180,409 (enpiroline) in the treatment of induced Plasmodium falciparum infections in healthy, non-immune subjects." 09/01/2013 - "mansoni infections in mice influence the PK profiles of enpiroline and mefloquine, leading to delayed clearance. " 09/01/2013 - "mansoni infection on the pharmacokinetic (PK) parameters of two promising antischistosomal lead candidates (mefloquine and enpiroline) in mice. "
2.	Parasitemia 07/01/1985 - "falciparum, parasitemia recurred following treatment with the candidate antimalarial drug enpiroline. "
3.	Schistosomiasis mansoni 09/01/2013 - "Disposition of mefloquine and enpiroline is highly influenced by a chronic Schistosoma mansoni infection."
4.	Malaria 01/01/1989 - "falciparum, but still requiring further investigations on resistance and cross-resistance, as well as its pharmacokinetics, tolerability and bioavailability; d) enpiroline, another promising compound, which needs to be further studied in Phase II and Phase III investigations with naturally acquired malaria. "
5.	Body Weight (Weight, Body) 06/01/2012 - "High worm burden reductions (WBR) were obtained with enpiroline (WBR, 82.7%; dosage, 200 mg/kg of body weight) and its threo isomers (+)-threo (WBR, 100%) and (-)-threo (WBR, 89%) and with WR7930 (WBR, 87%; dosage, 100 mg/kg) against adult S. "

Related Drugs and Biologics

1.	Mefloquine (Lariam)
2.	Antimalarials (Antimalarial Agents)