triciribine

structure

Also Known As:

3-amino-1,5-dihydro-5-methyl-I-beta-D-ribofuranosyl-1,4,5,6,8- pentaazaacenaphthylene; 6-ARPPP; 6-amino-4-methyl-8-(beta-D-ribofuranosyl)-(4H,8H)pyrrolo(4,3,2-de)pyrimido(4,5-c)pyridazine; NSC 154020; NSC 154120; NSC-154020; 1,4,5,6,8-Pentaazaacenaphthylen-3-amine, 1,5-dihydro-5-methyl-1-beta-D-ribofuranosyl-

Networked: 42 relevant articles (6 outcomes, 12 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - Ribonucleosides: 49
    - triciribine: 42

Experts

1.	Somanath, Payaningal R: 5 articles (01/2021 - 08/2015)
2.	Verma, Arti: 3 articles (01/2021 - 01/2017)
3.	Littlepage, Laurie E: 3 articles (11/2020 - 07/2012)
4.	Alwhaibi, Abdulrahman: 3 articles (01/2020 - 01/2017)
5.	Malafa, Mokenge: 3 articles (09/2015 - 09/2007)
6.	Sebti, Said: 3 articles (09/2015 - 09/2007)
7.	Cheng, Jin Q: 3 articles (05/2011 - 09/2007)
8.	Coppola, Domenico: 3 articles (05/2011 - 09/2007)
9.	Adil, Mir S: 2 articles (01/2021 - 01/2020)
10.	Wu, Junmin: 2 articles (11/2020 - 12/2017)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 12/12/2017 - "The AKT inhibitor triciribine in combination with paclitaxel has order-specific efficacy against Zfp217-induced breast cancer chemoresistance." 07/01/2012 - "Our data suggest that ZNF217 is a biomarker of poor prognosis and a therapeutic target in patients with breast cancer and that triciribine may be part of a personalized treatment strategy in patients overexpressing ZNF217. " 05/01/2011 - "In an ErbB2-driven breast tumor transgenic mouse model, the combination, but not single agent, treatment with triciribine and tipifarnib induces significant breast tumor regression. " 10/01/2007 - "When trastuzumab was combined with the Akt inhibitor triciribine, breast cancer cell growth was inhibited and apoptosis was induced. " 07/01/2012 - "Because previous clinical trials for triciribine did not include biomarkers of treatment efficacy, this study provides a rationale for revisiting triciribine in the clinical setting as a therapy for patients with breast cancer who overexpress ZNF217."
2.	Acute Lung Injury 01/01/2021 - "Akt inhibitor triciribine (TCBN) has demonstrated promising results in promoting recovery from advanced-stage acute lung injury in preclinical studies. " 01/01/2020 - "In the current study, Akt inhibition using triciribine (TCBN), given 48 h after lipopolysaccharide (LPS) administration, increased Tregs-promoted resolution of acute lung injury (ALI). "
3.	Hypoxia (Hypoxemia) 08/01/2015 - "The Akt inhibitor, triciribine, ameliorates chronic hypoxia-induced vascular pruning and TGFβ-induced pulmonary fibrosis." 02/01/2017 - "The aim of the present study was to investigate the radiosensitization effect of triciribine (TCN) on human esophageal squamous cell carcinoma (ESCC) in normoxia or hypoxia and its mechanism. "
4.	Neuroblastoma 09/11/2018 - "Together, we concluded that Rapamycin and Triciribine proved to be effective in the in vitro treatment of glioblastoma and neuroblastoma, by targeting their CSC population." 09/11/2018 - "In our study, Triciribine and Rapamycin were used to assess the role of inhibiting two different points of the Akt/mTOR pathway in vitro on U251 (glioblastoma) and SH-SY5Y (neuroblastoma) human cell lines and their CSCs. "
5.	Glioblastoma (Glioblastoma Multiforme) 09/11/2018 - "Together, we concluded that Rapamycin and Triciribine proved to be effective in the in vitro treatment of glioblastoma and neuroblastoma, by targeting their CSC population." 09/11/2018 - "In our study, Triciribine and Rapamycin were used to assess the role of inhibiting two different points of the Akt/mTOR pathway in vitro on U251 (glioblastoma) and SH-SY5Y (neuroblastoma) human cell lines and their CSCs. "

Related Drugs and Biologics

1.	Sirolimus (Rapamycin)
2.	Paclitaxel (Taxol)
3.	2- (1H- indazol- 4- yl)- 6- (4- methanesulfonylpiperazin- 1- ylmethyl)- 4- morpholin- 4- ylthieno(3,2- d)pyrimidine
4.	2- (4- morpholinyl)- 8- phenyl- 4H- 1- benzopyran- 4- one
5.	Urocortins
6.	dactolisib
7.	Nucleosides
8.	API 2
9.	MicroRNAs (MicroRNA)
10.	Tacrolimus (Prograf)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)