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estradiol mustard

Also Known As:

NSC 112259; p-(N,N-bis(2-chloroethyl)amino)phenylacetic acid 17-beta-estradiol diester

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        estradiol mustard: 7

Experts

1.	Mayatskaya, E E: 1 article (06/2000)
2.	Rzheznikov, V M: 1 article (06/2000)
3.	Semeikin, A V: 1 article (06/2000)
4.	Smirnova, Z S: 1 article (06/2000)

Related Diseases

1.	Body Weight (Weight, Body) 01/01/1978 - "Mean body weights of male rats and male and female mice administered estradiol mustard were lower throughout the greater part of the study than those of corresponding vehicle or untreated controls; mean body weights of dosed female rats were unaffected. " 01/01/1978 - "Groups of 35 rats and 34-36 mice of each sex were administered estradiol mustard at one of the following doses, either 0.62 or 1.25 mg/kg body weight for rats and either 15 or 30 mg/kg body weight for mice. "
2.	Carcinoma (Carcinomatosis) 09/01/1973 - "Treatment in vivo of R3230AC carcinoma of the rat with estradiol mustard (NSC-112259) of its molecular components." 01/01/1978 - "Estradiol mustard was carcinogenic in both male and female B6C3F1 mice, inducing lymphoma, sarcoma of the myocardium, alveolar adenoma or carcinoma, and squamous-cell carcinoma of the stomach. " 05/01/1985 - "Estramustine phosphate (0.01 to 0.5 mM), an estradiol mustard derivative used in the therapy of prostatic carcinoma, inhibited the assembly of brain microtubules proteins in vitro and disassembled preformed microtubules. "
3.	Sarcoma (Soft Tissue Sarcoma) 06/01/2000 - "The effects of four new synthetic bis-beta-chloroethylamine-containing estrogens and known cytostatic agents chlorophenacyl and estradiol mustard were compared on monolayer cultures of transformed L-929 fibroblasts (from murine skin sarcoma). " 01/01/1978 - "Estradiol mustard was carcinogenic in both male and female B6C3F1 mice, inducing lymphoma, sarcoma of the myocardium, alveolar adenoma or carcinoma, and squamous-cell carcinoma of the stomach. "
4.	Neoplasms (Cancer) 01/01/1978 - "In rats, no tumors were observed in a statistically significant incidence in the animals administered estradiol mustard. " 01/01/1978 - "Although the incidences in this bioassay were too low to be statistically significant, the fact that no squamous-cell carcinomas of the stomach have occurred in the more than 500 male and 500 female historical-control mice of this strain at this laboratory indicates that these gastric tumors were related to the administration of the estradiol mustard. " 08/01/1975 - "The effects of the following cancer chemotherapeutic agents on serum hormonal levels, estrous cycles, and endocrine organs were studied in mature, normal Sprague-Dawley rats by radioimmunoassay, vaginal smear examination, and organ weight end point: estradiol mustard (NSC 112259), testosterone mustard (NSC 112260), phenoestrin (NSC 104469), methotrexate (NSC 740), 5-fluorouracil (NSC 19893), vinblastine (NSC 49842), vincristine (NSC 67574), nitrogen mustard (NSC 762), and 1,3-bis(2-chloroethyl)-1-nitrosourea (NSC 409962). "
5.	Lymphoma (Lymphomas) 01/01/1978 - "The results indicated a dose association (P=0.001) between the administration of estradiol mustard and the time of observation of lymphoma in either sex of mice. " 01/01/1978 - "Estradiol mustard was carcinogenic in both male and female B6C3F1 mice, inducing lymphoma, sarcoma of the myocardium, alveolar adenoma or carcinoma, and squamous-cell carcinoma of the stomach. "

Related Drugs and Biologics

1.	Phosphates (Orthophosphate)
2.	Estramustine
3.	estradiol mustard
4.	Cytostatic Agents
5.	Vincristine (Oncovin)
6.	Vinblastine (Vinblastine Sulfate)
7.	Estrogen Receptors
8.	Proteins (Proteins, Gene)
9.	Methotrexate (Mexate)
10.	Mechlorethamine (Nitrogen Mustard)

Related Therapies and Procedures

1.	Therapeutics