acetamidine

bovine trypsin inhibitor; RN given refers to parent cpd; structure

Also Known As:

acetamidine hydrochloride; acetamidine monoacetate; acetamidine monohydrochloride; acetamidine sulfate (1:1); acetamidinium

Networked: 24 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amidines: 14
  - acetamidine: 24

Experts

1.	Amoroso, Rosa: 2 articles (06/2020 - 01/2019)
2.	Maccallini, Cristina: 2 articles (06/2020 - 01/2019)
3.	Guo, Jin Sheng: 2 articles (05/2006 - 12/2004)
4.	Koo, Marcel Wing Leung: 2 articles (05/2006 - 12/2004)
5.	Belvisi, Maria G: 2 articles (11/2004 - 03/2003)
6.	Birrell, Mark A: 2 articles (11/2004 - 03/2003)
7.	McCluskie, Kerryn: 2 articles (11/2004 - 03/2003)
8.	Bellezza, Ilaria: 1 article (06/2020)
9.	D'Onofrio, Fiorella: 1 article (06/2020)
10.	Fettucciari, Katia: 1 article (06/2020)

Related Diseases

1.	Glioma (Gliomas) 01/24/2019 - "The Selective Acetamidine-Based iNOS Inhibitor CM544 Reduces Glioma Cell Proliferation by Enhancing PARP-1 Cleavage In Vitro." 01/24/2019 - "The present work was to analyze the molecular effects of the acetamidine derivative compound 39 (formally CM544, N-(3-{[(1-iminioethyl)amino]methyl}benzyl) prolinamide dihydrochloride), a newly synthetized iNOS inhibitor, in a C6 rat glioma cell model. " 01/01/1999 - "Studies were conducted using a novel in vitro approach to investigate the efficacy of acetamidine hydrochloride (ACE) and guanidine hydrochloride (GUAN), previously shown to block gramicidin D (GRAM) channels in artificial membranes, in preventing the toxic effects of GRAM in NG108-15 (neuroblastoma x glioma hybrid) cells. "
2.	Cardiotoxicity 01/01/2011 - "In this study, the possible protective effects of melatonin (MEL), mercaptoethylguanidine (MEG), or N-(3-(aminomethyl) benzyl) acetamidine (1400W) against the cardiotoxicity of DOX and TRAST were tested. "
3.	Neuroblastoma 01/01/1999 - "Studies were conducted using a novel in vitro approach to investigate the efficacy of acetamidine hydrochloride (ACE) and guanidine hydrochloride (GUAN), previously shown to block gramicidin D (GRAM) channels in artificial membranes, in preventing the toxic effects of GRAM in NG108-15 (neuroblastoma x glioma hybrid) cells. "
4.	Thrombosis (Thrombus) 01/01/2023 - "N-(3-(aminomethyl) benzyl) acetamidine attenuated large artery vasospasm and microvessel thrombosis and improved neurological deficits in wild-type animals. "
5.	Myocardial Infarction 05/01/2012 - "The hemodynamic parameters were all markedly improved during the reperfusion period, and the myocardial infarct size was significantly reduced by delayed sevoflurane preconditioning in normocholesterolemic rats, but all of these improvements were reversed by N-(3-(aminomethyl)benzyl) acetamidine (1400W, 1 mg/kg; i.v., 10 min before ischemia), a selective inducible NOS (iNOS) inhibitor, and 5-hydroxy decanoate sodium (5 mg/kg, i.v., 10 min before ischemia), a mitochondrial ATP-dependent K⁺ channel blocker. "

Related Drugs and Biologics

1.	Guanidine (Guanidine Nitrate)
2.	Artificial Membranes (Artificial Membrane)
3.	Melatonin
4.	Gramicidin (Gramicidin A)
5.	2-mercaptoethylguanidine
6.	Sodium
7.	Adenosine Triphosphate (ATP)
8.	Sevoflurane (Ultane)
9.	NG-Nitroarginine Methyl Ester (L-NAME)
10.	Nitric Oxide Synthase (NO Synthase)

Related Therapies and Procedures

1.	Resuscitation
2.	Injections