dienogest

structure given in first source

Also Known As:

17 alpha-cyanomethyl-17 beta-hydroxy-13 beta-methylgona-4,9-dien-3-one; 17 alpha-cyanomethyl-17 beta-hydroxyestra-4,9(10)-diene-3-one; 19-norpregna-4,9-diene-21-nitrile, 17-hydroxy-3-oxo-, (17alpha)-; STS 557; STS-557

Networked: 332 relevant articles (101 outcomes, 109 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Estranes
      - Estrenes
        Nandrolone: 245
        dienogest: 332
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Testosterone Congeners: 112
        Nandrolone: 245
        dienogest: 332

Experts

1.	Osuga, Yutaka: 17 articles (10/2020 - 05/2008)
2.	Koga, Kaori: 10 articles (10/2020 - 09/2011)
3.	Lee, Dong-Yun: 8 articles (01/2022 - 11/2016)
4.	Fujii, Tomoyuki: 8 articles (10/2020 - 09/2014)
5.	Harada, Miyuki: 8 articles (10/2020 - 09/2011)
6.	Hirota, Yasushi: 8 articles (10/2020 - 05/2008)
7.	Shimizu, Yutaka: 8 articles (07/2017 - 10/2009)
8.	Ferrero, Simone: 7 articles (10/2021 - 09/2014)
9.	Mita, Shizuka: 7 articles (03/2021 - 10/2009)
10.	Parke, Susanne: 7 articles (04/2020 - 04/2011)

Related Diseases

1.	Endometriosis 10/01/2018 - "We hereby report the clinical case of a cerebral localization of endometriosis treated with dienogest who experienced a complete remission of the disease." 10/01/2018 - "Complete remission of cerebral endometriosis with dienogest: a case report." 10/01/2018 - "This study aimed to assess whether dienogest (DNG) is also effective in patients with recurrent endometriosis based on multicenter data of 121 women who were clinically diagnosed as having recurrent endometriosis and treated for more than 24 weeks with DNG (2 mg daily). " 11/01/2023 - "Dienogest is superior to placebo and similar to GnRHa in decreasing rate of recurrence after endometriosis surgery. " 01/01/2022 - "Results suggest that TCM combined with Dienogest is superior to Dienogest or TCM alone and can be used as a complementary treatment for endometriosis. "
2.	Pain (Aches) 04/01/2017 - "Dienogest is an effective medication to control symptoms of pain related to DIE, even without reducing the volume of DIE nodules." 01/01/2021 - "The finding of the present study revealed that there is no difference in the efficacy of dienogest and OCPs in management of pain and the QOL. " 11/01/2023 - "A significantly higher reduction of pain after dienogest compared with placebo was reported in two separate studies, whereas a trend toward reduction of pain at 6 months was evident at meta-analysis. " 11/01/2023 - "In the secondary analysis, a trend toward reduction of pain at 6 months was reported in patients treated with dienogest over placebo, with each study reporting a significantly higher reduction of pain after dienogest treatment. " 10/01/2021 - "Out of 41 patients (73%) who had severe pain at enrollment, only 1 patient (1.79%) complained of severe pain at the end of 1 month with dienogest. "
3.	Pelvic Pain 01/01/2023 - "After 6 months follow-up assessments the pelvic pain score was significantly lower in Dienogest group than MPA group (P < 0.001). " 01/01/2012 - "A significant decrease in pelvic pain was shown during continued dienogest treatment (P < 0.001). " 09/01/2015 - "The extended therapy with dienogest 2 mg/day also showed an improvement in pelvic pain after 24-52 weeks (-22.5 ± 32.1 and -28.4 ± 29.9 mm, respectively) with tolerable side effects. " 11/12/2010 - "In randomized clinical trials, oral dienogest was significantly more effective than placebo in reducing pelvic pain in patients with confirmed endometriosis. " 12/01/2021 - "Both treatments improved the mean VAS score for endometriosis-associated pelvic pain significantly: mean difference 6.0 [95% confidence interval (CI) 4.9-7.1; p < 0.0001] in the dienogest group and 4.54 (95% CI 3.1-5.9; p < 0.0001) in the COC group; the difference between them was not significant (p = 0.111). "
4.	Adenomyosis 08/01/2021 - "Dienogest and COCs are effective in treating adenomyosis-associated symptoms after 6 months of use but dienogest is more effective. " 09/01/2017 - "We aimed to investigate the safety and efficacy of dienogest (DNG), a progestational 19-norsteroid, administered for 52 weeks in patients with symptomatic adenomyosis. " 10/01/2014 - "Efficacy of dienogest in the treatment of symptomatic adenomyosis: a pilot study." 01/01/2018 - "The Effects of Dienogest on Macrophage and Natural Killer Cells in Adenomyosis: A Randomized Controlled Study." 10/01/2017 - "Evaluation of the efficacy and safety of dienogest in the treatment of painful symptoms in patients with adenomyosis: a randomized, double-blind, multicenter, placebo-controlled study."
5.	Hemorrhage 06/30/2000 - "The most favourable bleeding profile was seen in the 3.0 mg dienogest group, whereas the lower doses of dienogest had advantages with respect to the efficacy of the combined preparation. " 08/01/2021 - "Bleeding pattern was improved greatly; uterine volume and uterine artery blood flow decreased significantly in the dienogest group. " 01/01/2015 - "The bleeding pattern associated with dienogest 2 mg was well tolerated, and only two women (0.6%) reported bleeding events as the primary reason for premature discontinuation. " 03/01/2010 - "As expected, bleeding episodes were suppressed less with dienogest than with LA. " 01/01/2016 - "Intraoperative data showed no significant difference between the two groups for cervical dilatation time (p = 0.326), while in the Dienogest group, we found a significant reduction of operative time (p = 0.001), infusion volume (p = 0.001), and severity of bleeding (p = 0.042). "

Related Drugs and Biologics

1.	Progestins (Progestagens)
2.	Gonadotropin-Releasing Hormone (GnRH)
3.	Levonorgestrel (Plan B)
4.	Estradiol (Delestrogen)
5.	Oral Contraceptives
6.	Hormones (Hormone)
7.	Contraceptive Agents (Contraceptives)
8.	Valerates
9.	Combined Oral Contraceptives
10.	Progesterone Receptors (Progesterone Receptor)

Related Therapies and Procedures

1.	Therapeutics
2.	Contraception (Birth Control)
3.	Operative Time
4.	Cystectomy
5.	Hormonal Contraception