pregna-4,17-diene-3,16-dione (guggulsterone)

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17 relevant articles (2 outcomes, 6 trials/studies) found for this Bio-Agent

Description: steroid from guggulu extract; RN & N1 from C1 Form index; RN given refers to cpd without isomeric designation; structure in first source; antagonist of farnesoid X receptor

Also Known As:

guggulsterone; (Z)-guggulsterone; pregna-4,17-diene-3,16-dione, (17E)-isomer; pregna-4,17-diene-3,16-dione, (17Z)-isomer; (17E)-pregna-4,17(20)-diene-3,16-dione

Relationship Network

Bio-Agent Context: Research Results

Polycyclic Compounds: 58

pregna-4,17-diene-3,16-dione: 17

Experts

1.	Xiao, Dong: 2 articles (08/2007 - 11/2005)
2.	Singh, Shivendra V: 2 articles (08/2007 - 11/2005)
3.	Zeng, Yan: 2 articles (08/2007 - 11/2005)
4.	Aggarwal, Bharat B: 2 articles (06/2007 - 01/2006)
5.	Hahm, Eun-Ryeong: 1 article (08/2007)
6.	Choi, Sunga: 1 article (08/2007)
7.	Shishodia, Shishir: 1 article (06/2007)
8.	Sethi, Gautam: 1 article (06/2007)
9.	Ahn, Kwang Seok: 1 article (06/2007)
10.	Kim, Jung Mogg: 1 article (12/2006)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 01/01/2008 - "Together, our results provide compelling rationale for further preclinical and clinical investigation of z-guggulsterone for its efficacy against prostate cancer." 01/01/2008 - "Our previous studies have shown that z-guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis" 11/01/2005 - "The present study was undertaken to gain insights into the molecular mechanism of cell death (apoptosis) by guggulsterone, a constituent of Ayurvedic medicinal plant Commiphora mukul, using PC-3 human prostate cancer cells as a model" 01/01/2008 - "The z-guggulsterone treatment inhibited capillary-like tube formation (in vitro neovascularization) by human umbilical vein endothelial cells (HUVEC) and migration by HUVEC and DU145 human prostate cancer cells in a concentration- and time-dependent manner" 08/01/2007 - "The guggulsterone treatment caused generation of ROI in prostate cancer cells but not in a normal prostate epithelial cell line (PrEC), which was also resistant to guggulsterone-mediated JNK activation" Order ALL the reference details at left...
2.	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 12/01/2006 - "It remains unknown, however, whether guggulsterone is effective for the treatment of inflammatory bowel disease (IBD)" Order ALL the reference details at left...
3.	Colitis 12/01/2006 - "Administration of guggulsterone significantly reduced the severity of DSS-induced murine colitis as assessed by clinical disease activity score, colon length, and histology" 12/01/2006 - "Therefore, we investigated anti-inflammatory effects of guggulsterone on intestinal epithelial cells (IEC) and on experimental murine colitis models and elucidated its molecular mechanisms" 12/01/2006 - "Plant sterol guggulsterone inhibits nuclear factor-kappaB signaling in intestinal epithelial cells by blocking IkappaB kinase and ameliorates acute murine colitis." 12/01/2006 - "CONCLUSION: Guggulsterone blocks NF-kappaB signaling pathway by targeting IKK complex in IEC and attenuates DSS-induced acute murine colitis, which suggests that guggulsterone could be an attractive therapeutic option in the treatment of IBD." Order ALL the reference details at left...
4.	Neoplasms (Cancer) 12/01/2008 - "The plant sterol guggulsterone has been shown to exert anti-tumor effects, making it a candidate chemotherapeutic agent" 08/01/2007 - "Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, causes apoptosis in cancer cells but the sequence of events leading to cell death is poorly understood" 01/15/2006 - "We investigated whether guggulsterone could modulate RANKL signaling and osteoclastogenesis induced by RANKL or tumor cells" 12/01/2008 - "We investigated the anti-tumor effects of guggulsterone on colon cancer cells and elucidated the underlying molecular mechanisms related to angiogenesis" 01/01/2008 - "Oral gavage of 1 mg z-guggulsterone/d (five times/wk) to male nude mice inhibited in vivo angiogenesis in DU145-Matrigel plug assay as evidenced by a statistically significant decrease in tumor burden, microvessel area (staining for angiogenic markers factor VIII and CD31), and VEGF-R2 protein expression" Order ALL the reference details at left...
5.	Hyperlipidemias (Hyperlipidemia) 07/01/1996 - "A study of effect of guggulsterone on hyperlipidemia of secondary glomerulopathy." 07/16/2008 - "Guggulsterone has been used to treat hyperlipidemia, arthritis, and obesity" 06/06/2008 - "Guggulsterone is a plant sterol that is used to treat hyperlipidemia, arthritis, and obesity" 06/30/2007 - "Guggulsterone is a plant polyphenol traditionally used to treat obesity, diabetes, hyperlipidemia, atherosclerosis, and osteoarthritis, possibly through an anti-inflammatory mechanism" 11/05/2004 - "Guggulsterone, derived from Commiphora mukul and used to treat obesity, diabetes, hyperlipidemia, atherosclerosis, and osteoarthritis, has been recently shown to antagonize the farnesoid X receptor and decrease the expression of bile acid-activated genes" Order ALL the reference details at left...

Related Drugs and Biologics

1.	I-kappa B Kinase
2.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
3.	Androgen Receptors (Androgen Receptor)
4.	NF-kappa B (NF-kB)
5.	Isoproterenol (Isoprenaline)
6.	guggulu extract
7.	RANK Ligand
8.	Caspase 3 (Caspase-3)
9.	JNK Mitogen-Activated Protein Kinases
10.	Cyclin D1

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