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glycocalicin

glycoprotein component of outer surface of intact platelets; inhibits platelet aggregation induced by thrombin or by ristocetin (mol wt 150,000)
Also Known As:
platelet glycoprotein GPIb alpha fragment; soluble glycoprotein Ib alpha
Networked: 36 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Esselink, Mariet T: 2 articles (05/2005 - 05/2005)
2. Vellenga, Edo: 2 articles (05/2005 - 05/2005)
3. Smit, Jan W: 2 articles (05/2005 - 05/2005)
4. Houwerzijl, Ewout J: 2 articles (05/2005 - 05/2005)
5. de Wolf, Joost Th M: 2 articles (05/2005 - 05/2005)
6. Louwes, Henk: 2 articles (05/2005 - 05/2005)
7. Page, Sandy: 1 article (05/2015)
8. Kleiner, David E: 1 article (05/2015)
9. Moon, Mi Sun: 1 article (05/2015)
10. Zhao, Xiongce: 1 article (05/2015)

Related Diseases

1. Hemorrhage
2. Stroke (Strokes)
3. Thrombocytopenia (Thrombopenia)
4. Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune)
05/01/2005 - "Increased glycocalicin index and normal thrombopoietin levels in patients with idiopathic thrombocytopenic purpura with a decreased rate of platelet production."
03/01/1984 - "An immunoradiometric assay was developed to quantify plasma glycocalicin, and normal plasma was found to contain approximately 1-3 micrograms/ml. The plasma of a patient with severe thrombocytopenia due to aplastic anemia had less than 12.5% of the normal level of glycocalicin, whereas two patients with thrombocytopenia due to diseases of increased platelet destruction (idiopathic thrombocytopenic purpura and hemolytic-uremic syndrome) had normal levels. "
07/01/1996 - "Using enzyme-linked immunosorbent assays, we measured the concentrations of serum thrombopoietin (TPO) and plasma glycocalicin, a proteolytic fragment of platelet glycoprotien Ib alpha, in 13 patients with myelodysplastic syndrome (MDS), aplastic anaemia (AA) or idiopathic thrombocytopenic purpura (ITP). "
09/01/2006 - "To evaluate the mechanisms underlying prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation (SCT), an index for plasma glycocalicin normalized for the individual platelet count (GCI), plasma thrombopoietin (TPO), and circulating B cells producing anti-GPIIb-IIIa antibodies were measured in 50 SCT recipients with or without prolonged thrombocytopenia, 42 patients with idiopathic thrombocytopenic purpura, nine patients with aplastic anemia, and 22 healthy individuals. "
01/01/2015 - "MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. "
5. Aplastic Anemia (Anemia, Hypoplastic)
10/22/1987 - "All of eight patients with aplastic anemia or amegakaryocytic thrombocytopenia confirmed by examining bone marrow (in all patients) and by determining the life span of autologous platelets (in six patients) had glycocalicin levels significantly below the normal range (5 to 27 percent). "
11/01/1993 - "Plasma samples from four patients with aplastic anemia and ten patients with myelodysplastic syndromes, all with glycocalicin levels less than 0.6 mg/L by an enzyme-linked immunosorbent assay, all had negative results by the latex test. "
03/01/1984 - "An immunoradiometric assay was developed to quantify plasma glycocalicin, and normal plasma was found to contain approximately 1-3 micrograms/ml. The plasma of a patient with severe thrombocytopenia due to aplastic anemia had less than 12.5% of the normal level of glycocalicin, whereas two patients with thrombocytopenia due to diseases of increased platelet destruction (idiopathic thrombocytopenic purpura and hemolytic-uremic syndrome) had normal levels. "
09/01/2006 - "To evaluate the mechanisms underlying prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation (SCT), an index for plasma glycocalicin normalized for the individual platelet count (GCI), plasma thrombopoietin (TPO), and circulating B cells producing anti-GPIIb-IIIa antibodies were measured in 50 SCT recipients with or without prolonged thrombocytopenia, 42 patients with idiopathic thrombocytopenic purpura, nine patients with aplastic anemia, and 22 healthy individuals. "
01/01/2015 - "MPV, glycocalicin and platelet-associated IgG (PA-IgG) were measured in 107 patients with idiopathic thrombocytopenic purpura (ITP) and 19 patients with hypoproductive thrombocytopenia (HPT; aplastic anemia or leukemia), and TPO was measured in 53 ITP and 12 HPT patients. "

Related Drugs and Biologics

1. Glycoproteins (Glycoprotein)
2. Thrombin
3. Chymotrypsin
4. Thrombopoietin (c-mpl Ligand)
5. Platelet Glycoprotein GPIb-IX Complex (Glycoprotein Ib)
6. P-Selectin
7. von Willebrand Factor
8. Inosine Triphosphate (ITP)
9. Antibodies
10. Complementary DNA (cDNA)

Related Therapies and Procedures

1. Transplants (Transplant)
2. Hematopoietic Stem Cell Transplantation
3. Renal Dialysis (Hemodialysis)