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dactimicin
related to fortimicin A; structure given in first source
Also Known As:
SF-2052; ST 900; ST-900; L-chiro-Inositol, 4-amino-1,4-dideoxy-3-O-(2,6-diamino-2,3,4,6,7-pentadeoxy-beta-L-lyxo-heptopyranosyl)-1-((((iminomethyl)amino)acetyl)methylamino)-6-O-methyl-
Networked:
8
relevant articles (
2
outcomes,
1
trials/studies)
Relationship Network
Bio-Agent Context: Research Results
Carbohydrates: 22023
Glycosides: 2119
Aminoglycosides: 5131
dactimicin: 8
Related Diseases
1.
Intraabdominal Infections
01/01/1989 - "
Efficacy of dactimicin in the treatment of experimentally induced intra-abdominal infections.
"
01/01/1989 - "
Antimicrobial activity of dactimicin against aerobic and anaerobic bacteria isolated from intra-abdominal infections.
"
01/01/1990 - "
Thus the combination dactimicin/clindamycin seems to be useful in the treatment of intra-abdominal infections.
"
01/01/1989 - "
Thus the combination dactimicin and metronidazole seems to be useful in the treatment of intra-abdominal infections.
"
01/01/1990 - "
The experimental model was used to compare the efficacy of dactimicin in combination with clindamycin with the combination gentamicin/clindamycin in the treatment of intra-abdominal infections.
"
2.
Ototoxicity
01/01/1987 - "
Animal toxicity studies show that the ototoxicity and nephrotoxicity of dactimicin are lower than those of amikacin and gentamicin.
"
01/01/1989 - "
Based on these observations, it is concluded that the ototoxicity of dactimicin on the inner ear of guinea pigs is the same as or a little stronger than that of ribostamycin, weaker than or the same as that of astromicin and weaker than amikacin.
"
01/01/1990 - "
Comparative ototoxicity of ribostamycin, dactimicin, dibekacin, kanamycin, amikacin, tobramycin, gentamicin, sisomicin and netilmicin in the inner ear of guinea pigs.
"
01/01/1990 - "
Nine aminoglycoside antibiotics, ribostamycin (RSM), dactimicin (DAC), dibekacin (DKB), kanamycin (KM), amikacin (AMK), netilmicin (NTL), tobramycin (TOB), gentamicin (GM) and sisomicin (SISO) were administered intramuscularly to guinea pigs for 4 weeks, and ototoxicity and drug concentration in the inner ear fluid were determined.
"
3.
Infections
01/01/1989 - "
The data obtained show that dactimicin is a promising new aminoglycoside covering aerobic bacteria and that it may be used together with an antianaerobic agent in the treatment of these infections.
"
04/01/1985 - "
The in vivo activity of dactimicin, assessed by the 50% effective doses against systemic infections in mice, was similar or superior to that of astromicin and was superior or inferior to that of amikacin depending on the strains tested.
"
01/01/1987 - "
Dactimicin (ST 900) is a new pseudo-disaccharide aminoglycoside antibiotic which has been shown to be active against systemic infections in mice.
"
Related Drugs and Biologics
1.
Gentamicins (Gentamicin)
2.
Metronidazole (Metric)
3.
Clindamycin (Cleocin)
4.
Amikacin (A.M.K)
5.
Aminoglycosides
6.
Ribostamycin
7.
Anti-Bacterial Agents (Antibiotics)
8.
dactimicin
9.
fortimicin A
10.
Tobramycin (Nebcin)