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tetrahydroneopterin

Also Known As:

5,6,7,8-tetrahydroneopterin; tetrahydro-d-monapterin; 2-amino-5,6,7,8-tetrahydro-6-(1,2,3-trihydroxypropyl)-4(1H)-pteridinone

Networked: 5 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Pteridines: 147
      - Pterins: 160
        Biopterins: 249
        tetrahydroneopterin: 5
Enzymes and Coenzymes: 1
- Coenzymes: 558
  - Biopterins: 249
    - tetrahydroneopterin: 5

Experts

1.	Watanabe, Takuya: 1 article (04/2021)

Related Diseases

1.	Radiation Injuries (Radiation Sickness) 03/30/1999 - "The protective effects of 5,6,7,8-tetrahydroneopterin (NH4) against radiation injury in mice were studied. " 03/30/1999 - "Protective effects of 5,6,7,8-tetrahydroneopterin against X-ray radiation injury in mice."
2.	Cardiotoxicity 09/01/1993 - "Inhibitory effect of 5,6,7,8-tetrahydroneopterin on adriamycin-induced cardiotoxicity." 05/25/1993 - "The therapeutic potency of 5,6,7,8-tetrahydroneopterin (NPH4) was investigated in ischemic paw edema, Adriamycin (ADR)-induced cardiotoxicity, and endotoxin [lipopolysaccharide (LPS)]- and carbon tetrachloride (CCl4)-induced hepatotoxicity in mice. " 09/01/1993 - "The protective effect of the reduced form of neopterin, 5,6,7,8-tetrahydroneopterin (NPH4), against the cardiotoxicity of adriamycin (ADR) was evaluated in mice by assay of serum creatine phosphokinase (CPK) and heart lipid peroxide (i.e., thiobarbituric acid reactive substances, TBARS). "
3.	Atherosclerosis 12/01/1996 - "Since oxidative modification of low-density lipoprotein (LDL) and uptake of the oxidized LDL by macrophages are closely related to the pathogenesis of atherosclerosis, we examined the inhibitory effect of 5,6,7,8-tetrahydroneopterin (NPH4) on Cu(II)-induced lipid peroxidation of LDL. " 04/01/2021 - "A neopterin derivative tetrahydroneopterin (BH4), also known as a cofactor for nitric oxide (NO) synthases, suppresses atherosclerosis and vascular injury-induced neointimal hyperplasia in Apoe-/- mice. "
4.	Vascular System Injuries 04/01/2021 - "A neopterin derivative tetrahydroneopterin (BH4), also known as a cofactor for nitric oxide (NO) synthases, suppresses atherosclerosis and vascular injury-induced neointimal hyperplasia in Apoe-/- mice. "
5.	Hyperplasia 04/01/2021 - "A neopterin derivative tetrahydroneopterin (BH4), also known as a cofactor for nitric oxide (NO) synthases, suppresses atherosclerosis and vascular injury-induced neointimal hyperplasia in Apoe-/- mice. "

Related Drugs and Biologics

1.	Neopterin
2.	Doxorubicin (Adriamycin)
3.	Thiobarbituric Acid Reactive Substances
4.	Nitric Oxide (Nitrogen Monoxide)
5.	LDL Lipoproteins (beta Lipoproteins)
6.	Lipopolysaccharides
7.	Lipid Peroxides
8.	Endotoxins
9.	Creatine Kinase (Creatine Phosphokinase)
10.	Carbon Tetrachloride (Tetrachloromethane)