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7-azaindole dimer

model hydrogen bonded base pair; structure given in above citation
Also Known As:
7-azaindole
Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Dvořák, Zdeněk: 2 articles (01/2015 - 01/2014)
2. Trávníček, Zdeněk: 2 articles (01/2015 - 01/2014)
3. Starha, Pavel: 2 articles (01/2014 - 06/2013)
4. Horrillo, Raquel: 1 article (03/2015)
5. Alzina, Soledad: 1 article (03/2015)
6. Esteve, Cristina: 1 article (03/2015)
7. De Alba, Jorge: 1 article (03/2015)
8. Miralpeix, Montserrat: 1 article (03/2015)
9. Gual, Sílvia: 1 article (03/2015)
10. Jover, Irene: 1 article (03/2015)

Related Diseases

1. Neoplasms (Cancer)
01/01/2014 - "The in vitro antitumour activity studies on a panel of human cancer cell lines (A549, HeLa, G-361, A2780, and A2780R) and the combined in vivo and ex vivo antitumour testing on the L1210 lymphocytic leukaemia model were performed on the cis-[PtCl2(naza)2] complexes (1-3) involving the 7-azaindole derivatives (naza). "
05/22/2014 - "Compound 12, (E)-3-(3-((1H-pyrrolo[2,3-b]pyridin-1-yl)sulfonyl)phenyl)-N-hydroxyacrylamide, which has a 7-azaindole core cap, was shown to have antiproliferative activity against KB, H460, PC3, HSC-3, HONE-1, A549, MCF-7, TSGH, MKN45, HT29, and HCT116 human cancer cell lines. "
06/01/2013 - "Insight into the toxic effects of cis-dichloridoplatinum(II) complexes containing 7-azaindole halogeno derivatives in tumor cells."
01/01/2015 - "The cis-[PtCl2(naza)2] complexes (1-3) containing monosubstituted 7-azaindole halogeno-derivatives (naza), showed significantly higher activity than cisplatin towards ovarian carcinoma A2780, its cisplatin-resistant variant A2780R, osteosarcoma HOS, breast carcinoma MCF7 and cervix carcinoma HeLa cell lines, with the IC50 values of 3.8, 3.5, 4.5, 2.7, and 9.2 μM, respectively, obtained for the most active complex 3. As for 4 and 5 having disubstituted 7-azaindoles in their molecule, the significant cytotoxicity was detected only for 4 against A2780 (IC50 = 4.8 μM), A2780R (IC50 = 3.8 μM) and HOS (IC50 = 4.3 μM), while 5 was evaluated as having only moderate antiproliferative effect against the mentioned cancer cell lines with IC50 = 33.4, 24.7 and 46.7 μM, respectively. "
2. Osteosarcoma (Osteogenic Sarcoma)
3. Carcinoma (Carcinomatosis)
4. Asthma (Bronchial Asthma)

Related Drugs and Biologics

1. Cisplatin (Platino)