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benzene oxide

RN given refers to parent cpd

Also Known As:

benzene oxide, conjugate acid; 7-oxabicyclo(4.1.0)hepta-2,4-diene

Networked: 7 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cyclohexanes: 3
        benzene oxide: 7

Experts

1.	Li, Guilan: 2 articles (09/2006 - 06/2003)
2.	Yin, Songnian: 2 articles (09/2006 - 06/2003)
3.	Waidyanatha, Suramya: 2 articles (02/2005 - 06/2003)
4.	Balbo, Silvia: 1 article (05/2014)
5.	Cheng, Guang: 1 article (05/2014)
6.	Hecht, Stephen S: 1 article (05/2014)
7.	Villalta, Peter W: 1 article (05/2014)
8.	Wang, Mingyao: 1 article (05/2014)
9.	Zarth, Adam T: 1 article (05/2014)
10.	Zhang, Zhaobin: 1 article (05/2014)

Related Diseases

1.	Carcinogenesis 05/25/2014 - "The results of this study do not support the hypothesis that the benzene oxide-DNA adduct 7-PhG is involved in carcinogenesis by benzene. "
2.	Chromosome Aberrations (Chromosome Abnormalities) 09/01/2006 - "Some of these are benzene oxide-protein adducts, chromosome aberration of lymphocytes, and GPA mutations in erythrocytes, a decrease in B cell and CD4(-)T cell counts in peripheral blood, and altered expression of CXCL16, ZNF331, JUN, and PF4 in lymphocytes. " 06/01/2003 - "The biomarkers evaluated were urinary metabolites S-phenylmercapturic acid (S-PMA*), trans,trans-muconic acid (t,t-MA), hydroquinone (HQ), catechol (CAT), and phenol; albumin adducts of benzene oxide and 1,4-benzoquinone (BO-Alb and 1,4-BQ-Alb, respectively) in blood; blood cell counts; and chromosomal aberrations. "
3.	Body Weight (Weight, Body) 09/15/1994 - "administration of a mixture of [14C]- and [13C6]benzene between 50 and 400 mg/kg body weight, cysteine adducts of benzene oxide, 1,2-BQ, and 1,4-BQ were assayed, and the proportions of cysteine-bound adducts to total protein binding were estimated. " 03/01/2000 - "The stability of cysteinyl adducts of benzene oxide (BO) and mono-S-substituted cysteinyl adducts of 1,4-benzoquinone (1,4-BQ) was investigated in both hemoglobin (Hb) and albumin (Alb) following administration of a single oral dose of 400 mg [U-14C/13C6]benzene/kg body weight to F344 rats. "
4.	Neoplasms (Cancer) 09/01/1990 - "This hypothesis was explored by testing benzene oxide (BzO) and enantiomers and racemates of benzene dihydrodiols and diolepoxides for their capacity to induce lung tumors in a newborn mouse assay. "
5.	Dehydration (Water Stress) 02/01/2005 - "Incubation of benzene oxide with N-acetyl-L-cysteine at 37 degrees C and pH 10.0 and subsequent mass spectrometric analysis of the mixture showed formation of pre-S-phenylmercapturic acid and the dehydration product, S-phenylmercapturic acid. " 02/01/2005 - "The reaction of intracellular glutathione with benzene oxide-oxepin, the initial metabolite of benzene, is presumed to give 1-(S-glutathionyl)-cyclohexa-3,5-dien-2-ol, which undergoes dehydration to S-phenylglutathione, the precursor of S-phenylmercapturic acid. "

Related Drugs and Biologics

1.	Benzene (Benzole)
2.	DNA Adducts
3.	Albumins
4.	S-phenyl-N-acetylcysteine
5.	quinone (benzoquinone)
6.	Phenol (Carbolic Acid)
7.	Biomarkers (Surrogate Marker)
8.	Proteins (Proteins, Gene)
9.	Oxepins (Oxepin)
10.	Hemoglobins (Hemoglobin)