|1.||Altaner, Cestmir: 5 articles (09/2014 - 10/2008)|
|2.||Hamada, Hirofumi: 5 articles (04/2011 - 10/2002)|
|3.||Hamada, H: 5 articles (01/2001 - 01/2000)|
|4.||Altanerova, Veronika: 4 articles (03/2014 - 10/2008)|
|5.||Kucerova, Lucia: 3 articles (07/2013 - 10/2008)|
|6.||Matuskova, Miroslava: 3 articles (07/2013 - 10/2008)|
|7.||Rychly, Boris: 2 articles (03/2014 - 05/2012)|
|8.||Cihova, Marina: 2 articles (03/2014 - 05/2012)|
|9.||Ondicova, Katarina: 2 articles (03/2014 - 05/2012)|
|10.||Mravec, Boris: 2 articles (03/2014 - 05/2012)|
|1.||Glioblastoma (Glioblastoma Multiforme)
05/15/2012 - "Human adipose tissue-derived mesenchymal stem cells expressing yeast cytosinedeaminase::uracil phosphoribosyltransferase inhibit intracerebral rat glioblastoma."
03/15/2014 - "In this study, we evaluated the therapeutic efficacy of human mesenchymal stem cells derived from bone marrow and from adipose tissue, engineered to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase to treat intracerebral rat C6 glioblastoma in a simulated clinical therapeutic scenario. "
05/15/2012 - "In this study, we tested the feasibility and efficacy of human adipose tissue-derived MSCs, engineered to express the suicide gene cytosine deaminase::uracil phosphoribosyltransferase to treat intracranial rat C6 glioblastoma. "
04/01/2011 - "NCAM2-mediated therapeutic gene transduction of uracil phosphoribosyltransferase (UPRT) had a highly effective cytotoxic effect on NCAM2-positive cancer cells, whereas it had less of an effect in cases with a control antibody. "
11/01/2004 - "To evaluate noninvasive measures of gene expression and tumor response in a gene-dependent enzyme prodrug therapy (GDEPT), a bifunctional fusion gene between Saccharomyces cerevisiae cytosine deaminase (CD) and Haemophilus influenzae uracil phosphoribosyltransferase (UPRT) was constructed. "
05/01/1998 - "Adenovirus-mediated transduction of Escherichia coli uracil phosphoribosyltransferase gene sensitizes cancer cells to low concentrations of 5-fluorouracil."
01/15/2005 - "In order to enhance the efficacy of conditionally replicating adenoviruses (CRAd) in the treatment of cancers of the biliary tract, we studied the efficacy in vitro and in vivo of AxE1CAUP, a CRAd vector that carries a gene for uracil phosphoribosyltransferase (UPRT), which converts 5-fluorouracil (5-FU) directly to 5-fluorouridine monophosphate and greatly enhances the cytotoxicity of 5-FU. "
10/01/2014 - "Here we show that the human adipose tissue-derived MSC expressing fusion yeast cytosine deaminase::uracil phosphoribosyltransferase (CD-MSC) in combination with 5-fluorocytosine (5FC) mediated a long-term tumor-free survival in the 83.3% of tumor-bearing animals. "
|3.||Prostatic Neoplasms (Prostate Cancer)
01/01/2009 - "This study was designed to investigate the prostate cancer-specific tumoricidal effect of the suicide gene, Escherichia coli uracil phosphoribosyltransferase (UPRT), driven by the human prostate-specific membrane antigen promoter/enhancer (PSMA(E/P)) in vitro. "
05/01/2008 - "To study the bystander effect of Uracil Phosphoribosyltransferase (UPRT )/5-fluorouracil (5-FU) suicide gene system, which is regulated by PSMA enhancer/promoter, on prostate cancer cell. "
05/01/2008 - "[Bystander effect of target-regulated uracil phosphoribosyltransferase/5-fluorouracil suicide gene system on prostate cancer cell]."
01/01/2003 - "Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system."
01/01/2009 - "Specific targeting of prostate cancer cells in vitro by the suicide gene/prodrug system, uracil phosphoribosyltransferase/5-fluorouracil, under the control of prostate-specific membrane antigen promoter/enhancer."
12/01/2003 - "The oncolytic effect of recombinant vesicular stomatitis virus is enhanced by expression of the fusion cytosine deaminase/uracil phosphoribosyltransferase suicide gene."
06/01/2011 - "In the present study, the synergistic activity of recombinant vesicular stomatitis virus (VSV)-MΔ51 virus expressing the cytosine deaminase/uracil phosphoribosyltransferase (CD::UPRT) suicide gene and 5-fluorocytosine (5FC) prodrug was investigated in triggering tumor cell oncolysis. "
10/01/2002 - "In this study, we investigated the ability of radiation therapy to enhance 5-fluorocytosine (5-FC)/cytosine deaminase (CD) plus uracil phosphoribosyltransferase (UPRT) gene therapy in malignant gliomas. "
05/01/2003 - "Murine glioma 261 (Gl261) cells were transduced with an adenoviral vector (Adex-CAUPTK) encoding both uracil phosphoribosyltransferase and thymidine kinase genes which sensitise cells to 5-fluorouracil (5-FU) and ganciclovir (GC), respectively. "
|5.||human glutamate carboxypeptidase II
|6.||Uridine Monophosphate (UMP)
|1.||Heterologous Transplantation (Xenotransplantation)
|3.||Drug Therapy (Chemotherapy)