|1.||Liu, Yong-Yu: 12 articles (02/2014 - 05/2004)|
|2.||Xie, Ping: 9 articles (12/2014 - 10/2006)|
|3.||Zhang, Bin: 7 articles (02/2014 - 10/2006)|
|4.||Cabot, Myles C: 7 articles (06/2013 - 05/2004)|
|5.||Gao, Peng: 6 articles (12/2012 - 02/2005)|
|6.||Gupta, Vineet: 6 articles (11/2012 - 01/2009)|
|7.||Shayman, James A: 5 articles (08/2015 - 07/2007)|
|8.||Cheng, Seng H: 5 articles (01/2015 - 07/2007)|
|9.||Aerts, Johannes M F G: 5 articles (07/2011 - 02/2007)|
|10.||Scheule, Ronald K: 4 articles (01/2015 - 01/2010)|
|1.||Gaucher Disease (Gaucher's Disease)
11/01/2006 - "RNAi-mediated inhibition of the glucosylceramide synthase (GCS) gene: A preliminary study towards a therapeutic strategy for Gaucher disease and other glycosphingolipid storage diseases."
10/01/2015 - "Eliglustat is a novel glucosylceramide synthase inhibitor for long-term oral treatment of type 1 Gaucher disease (GD1), an inherited metabolic disorder. "
10/01/2014 - "Eliglustat [Cerdelga™ (US, EU)], a small-molecule oral glucosylceramide analogue that inhibits the enzyme glucosylceramide synthase has been developed by Genzyme Corporation (a subsidiary of Sanofi) for the treatment of Gaucher disease type 1 in adults. "
10/01/2013 - "Characterization of variants in the glucosylceramide synthase gene and their association with type 1 Gaucher disease severity."
06/01/2013 - "Substrate reduction therapy utilises inhibitors of GlcCer synthase to reduce storage in Gaucher disease. "
03/01/1995 - "The best inhibitors of GlcCer synthase compared favorably in efficacy with some cancer chemotherapeutic drugs in current use when tested with a battery of human cancer cells."
01/01/2014 - "Studies on glucosylceramide synthase (GCS) activity suggest that this enzyme has a role in the development of multidrug resistance in many cancer cells. "
03/01/1995 - "Structural and stereochemical studies of potent inhibitors of glucosylceramide synthase and tumor cell growth."
08/01/2015 - "Glucosylceramide synthase (GCS) overexpression is associated with multidrug resistance in several human cancers. "
06/01/2015 - "Furthermore, ceramide glycosylation catalyzed by glucosylceramide synthase converts ceramide to glucosylceramide, thus eliminating ceramide and consequently protecting cancer cells from apoptosis. "
|3.||Fabry Disease (Fabry's Disease)
01/01/2015 - "Efficacy of Enzyme and Substrate Reduction Therapy with a Novel Antagonist of Glucosylceramide Synthase for Fabry Disease."
02/01/2000 - "Glycosphingolipid depletion in fabry disease lymphoblasts with potent inhibitors of glucosylceramide synthase."
06/01/2000 - "We used a potent inhibitor of glucosylceramide synthase to test whether substrate deprivation could lower globotriaosylceramide levels in alpha-galactosidase A (alpha-gal A) knockout mice, a model of Fabry disease. "
|4.||Lysosomal Storage Diseases (Lysosomal Storage Disease)
01/01/2012 - "These results reinforce the concept that systemically administered glucosylceramide synthase inhibitors could hold enhanced therapeutic promise for patients afflicted with neuropathic lysosomal storage diseases."
11/01/2013 - "Four representative pseudoglycolipids were also assayed as inhibitors of GlcCer synthase, because such compounds could find use in the substrate reduction therapy approach to treat lysosomal storage diseases, but these compounds revealed only moderate activity. "
05/01/2010 - "The iminosugar N-(5'-adamantane-1'-yl-methoxy)-pentyl-1-deoxynoijirimycin (AMP-DNM), an inhibitor of the enzyme glucosylceramide synthase catalyzing glycosphingolipid (GSL) biosynthesis, ameliorates diabetes and reduces liver steatosis in ob/ob mice. "
01/01/2011 - "Examples include the pharmacological inhibition of serine palmitoyltransferase or glucosylceramide synthase or the genetic depletion of acid sphingomyelinase, which dramatically reduce hepatic triglyceride levels in mice susceptible to the development of a fatty liver. "
|4.||N- (5- adamantane- 1- yl- methoxy- pentyl)deoxynojirimycin
|5.||tyrosine receptor (receptor, tyrosine)
|6.||RV 538 (PDMP)
|9.||tartaric acid (tartrate)
|1.||Drug Therapy (Chemotherapy)
|2.||Heterologous Transplantation (Xenotransplantation)